{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:13:46Z","timestamp":1770707626576,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1978,12,1]],"date-time":"1978-12-01T00:00:00Z","timestamp":281318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Early in life, mice of four kinds [NZB, (NZB \u00d7 NZW)F1, MRL\/1, and male BXSB] with autoimmune disease spontaneously produced far more (&amp;gt;3 S.D.) anti-hapten antibody-forming cells in spleens and greater concentrations of anti-hapten antibodies in sera than immunologically normal strains of mice (AKR, BALB\/c, C3H, C57BL\/6, DBA\/1J, DBA\/2J, LB\/J, 129, NZW, and female BXSB). This increased nonspecific antibody production by the abnormal animals' B cells correlated well with the spontaneous development of anti-single-stranded DNA antibodies, but not with serum levels of the viral envelope glycoprotein, gp70. These results suggest that the spontaneous formation of autoantibodies in mice whose immunologic disorder is manifested by a lupus-like disease may result from polyclonal activation of B cells by endogenous or exogenous B cell activators.<\/jats:p>","DOI":"10.4049\/jimmunol.121.6.2213","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:33:11Z","timestamp":1672446791000},"page":"2213-2219","source":"Crossref","is-referenced-by-count":200,"title":["Increased Spontaneous Polyclonal Activation of B Lymphocytes in Mice with Spontaneous Autoimmune Disease"],"prefix":"10.1093","volume":"121","author":[{"given":"Shozo","family":"Izui","sequence":"first","affiliation":[{"name":"Department of Immunopathology, Scripps Clinic and Research Foundation , La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia J","family":"McConahey","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Scripps Clinic and Research Foundation , La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Scripps Clinic and Research Foundation , La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,12,1]]},"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/121\/6\/2213\/62496488\/ji1210062213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/121\/6\/2213\/62496488\/ji1210062213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:10:06Z","timestamp":1743455406000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/121\/6\/2213\/8088780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.121.6.2213","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1978,12]]},"published":{"date-parts":[[1978,12,1]]}}}