{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:08:48Z","timestamp":1762067328848,"version":"3.40.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1979,4,1]],"date-time":"1979-04-01T00:00:00Z","timestamp":291772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human peripheral lymphoid cells pretreated with Concanavalin A for 48 hr can markedly suppress the proliferative response of untreated autologous lymphoid cells in MLC. Isolation studies with Sephadex G-200 anti-F(ab\u2032)2 affinity chromatography, nylon adherence, and E rosetting indicate that the Con A-induced suppressor cell is a T cell. Further fractionation into TH2+ and TH2- cell subsets with an equine-anti TH2 serum show that both subsets can be activated by Con A to an equivalent degree. After activation only the TH2+ subset can suppress autologous responder cells in MLC. The TH2- subset, which comprises 80% of peripheral human T cells, although induced by Con A to proliferate, cannot itself suppress the MLC response. Nevertheless, the TH2- subset can be shown to modulate the generation of suppressor TH2+ cells at 24 hr but not at 48 hr. These studies support the notion that the Con A-induced suppressor cell is confined to a distinct T cell subset in man and that T-T interactions are important in the overall expression of the immune response.<\/jats:p>","DOI":"10.4049\/jimmunol.122.4.1335","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T22:32:05Z","timestamp":1672439525000},"page":"1335-1341","source":"Crossref","is-referenced-by-count":104,"title":["Con A-Inducible Suppression of MLC: Evidence for Mediation by the TH2+ T Cell Subset in Man"],"prefix":"10.1093","volume":"122","author":[{"given":"Ellis L","family":"Reinherz","sequence":"first","affiliation":[{"name":"Harvard Medical School, Division of Tumor Immunology, Sidney Farber Cancer Institute , Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart F","family":"Schlossman","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Division of Tumor Immunology, Sidney Farber Cancer Institute , Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,4,1]]},"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/122\/4\/1335\/62496287\/ji1220041335.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/122\/4\/1335\/62496287\/ji1220041335.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:13:51Z","timestamp":1743455631000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/122\/4\/1335\/8088693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.122.4.1335","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[1979,4]]},"published":{"date-parts":[[1979,4,1]]}}}