{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T01:14:31Z","timestamp":1769649271571,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Survival of peripheral CD8+ T cells requires TCR interactions with peptide-MHC complexes (p-MHC). In the adult mouse, in the presence of homeostatic mechanisms that strictly control T cell numbers, it is likely that diverse T cell clones may compete for shared patterns of p-MHC. In the present study, we investigate whether the recognition of p-MHC overlaps between different T cell populations and what role does this process plays in the establishment of the peripheral T cell pools. Using an experimental strategy that follows the fate of adoptively transferred polyclonal T cells into RAG0\/0 or different TCR transgenic RAG0\/0 hosts, we demonstrate that T cells bearing different TCR specificities share identical TCR-specific requirements for survival and lymphopenia driven proliferation (LDP). This interclonal competition applies to both naive and activated\/memory T cells and is partially determined by the clone size of the established\/resident T cells. However, clonal competition with activated\/memory resident T cells impacts differently on the fate of newly produced bone-marrow-derived T cells or adoptively transferred peripheral T cells. Overall, our findings indicate that p-MHC define multiple diverse resource niches that can be shared by T cells from different compartments.<\/jats:p>","DOI":"10.4049\/jimmunol.0804071","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T01:07:38Z","timestamp":1240276058000},"page":"5232-5239","source":"Crossref","is-referenced-by-count":14,"title":["The Role of TCR Specificity and Clonal Competition During Reconstruction of the Peripheral T Cell Pool"],"prefix":"10.1093","volume":"182","author":[{"given":"Catarina","family":"Leit\u00e3o","sequence":"first","affiliation":[{"name":"Lymphocyte Population Biology Unit, Centre National de la Recherche Scientifique, Institut Pasteur , Paris,","place":["France"]}]},{"given":"Ant\u00f3nio A","family":"Freitas","sequence":"additional","affiliation":[{"name":"Lymphocyte Population Biology Unit, Centre National de la Recherche Scientifique, Institut Pasteur , Paris,","place":["France"]}]},{"given":"Sylvie","family":"Garcia","sequence":"additional","affiliation":[{"name":"Lymphocyte Population Biology Unit, Centre National de la Recherche Scientifique, Institut Pasteur , Paris,","place":["France"]}]}],"member":"286","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"2026012807021772600_R1","first-page":"591","article-title":"T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors.","volume-title":"J. 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