{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:01:55Z","timestamp":1767981715355,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lymph nodes (LNs) have been long considered as comprising few invariant NKT (iNKT) cells, and these cells have not been studied extensively. In this study, we unravel the existence of stable rather than transitional LN-resident NK1.1\u2212 iNKT cell populations. We found the one resident in peripheral LNs (PLNs) to comprise a major IL-17-producing population and to express the retinoic acid receptor-related orphan receptor \u03b3t (ROR\u03b3t). These cells respond to their ligand \u03b1-galactosylceramide (\u03b1-GalCer) in vivo by expanding dramatically in the presence of LPS, providing insight into how this rare population could have an impact in immune responses to infection. PLN-resident ROR\u03b3t+ NK1.1\u2212 iNKT cells express concomitantly CCR6, the integrin \u03b1-chain \u03b1E (CD103), and IL-1R type I (CD121a), indicating that they might play a role in inflamed epithelia. Accordingly, skin epithelia comprise a major ROR\u03b3t+ CCR6+CD103+CD121a+ NK1.1\u2212 cell population, reflecting iNKT cell composition in PLNs. Importantly, both skin and draining PLN ROR\u03b3t+ iNKT cells respond preferentially to inflammatory signals and independently of IL-6, indicating that they could play a nonredundant role during inflammation. Overall, our study indicates that ROR\u03b3t+ iNKT cells could play a major role in the skin during immune responses to infection and autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.0901059","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T00:36:40Z","timestamp":1247099800000},"page":"2142-2149","source":"Crossref","is-referenced-by-count":134,"title":["Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor \u03b3t+ and Respond Preferentially under Inflammatory Conditions"],"prefix":"10.1093","volume":"183","author":[{"given":"Jean-Marc","family":"Doisne","sequence":"first","affiliation":[{"name":"INSERM Unit\u00e9 561\/Groupe AVENIR, H\u00f4pital Cochin St. Vincent de Paul, Universit\u00e9 Descartes , Paris,","place":["France"]}]},{"given":"Chantal","family":"Becourt","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 561\/Groupe AVENIR, H\u00f4pital Cochin St. Vincent de Paul, Universit\u00e9 Descartes , Paris,","place":["France"]}]},{"given":"Latiffa","family":"Amniai","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 561\/Groupe AVENIR, H\u00f4pital Cochin St. Vincent de Paul, Universit\u00e9 Descartes , Paris,","place":["France"]}]},{"given":"Nadia","family":"Duarte","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 561\/Groupe AVENIR, H\u00f4pital Cochin St. Vincent de Paul, Universit\u00e9 Descartes , Paris,","place":["France"]}]},{"given":"Jean-Beno\u00eet","family":"Le Luduec","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 851, Institut F\u00e9d\u00e9ratif de Recherche 128 , Lyon,","place":["France"]}]},{"given":"G\u00e9rard","family":"Eberl","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Laboratory of Lymphoid Tissue Development, Centre National de la Recherche Scientifique Unit\u00e9 de Recherche Associ\u00e9e 1961 , Paris,","place":["France"]}]},{"given":"Kamel","family":"Benlagha","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 561\/Groupe AVENIR, H\u00f4pital Cochin St. Vincent de Paul, Universit\u00e9 Descartes , Paris,","place":["France"]}]}],"member":"286","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2025032709055827700_R1","first-page":"297","article-title":"The biology of NKT cells.","volume-title":"Annu. 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