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Using depletion of Treg mice, we showed that Foxp3+ Treg numbers increased rapidly during infection with the nematode Strongyloides ratti. Transient depletion of Tregs during the first days of infection led to dramatically reduced worm burden and larval output, without aggravation of immune pathology. The transient absence of Tregs during primary infection did not interfere with the generation of protective memory. Depletion of Tregs at later time points of infection (i.e., day 4) did not improve resistance, suggesting that Tregs exert their counterregulatory function during the priming of S. ratti-specific immune responses. Improved resistance upon early Treg depletion was accompanied by accelerated and prolonged mast cell activation and increased production of types 1 and 2 cytokines. In contrast, the blockade of the regulatory receptor CTLA-4 specifically increased nematode-specific type 2 cytokine production. Despite this improved immune response, resistance to the infection was only marginally improved. Taken together, we provide evidence that Treg expansion during S. ratti infection suppresses the protective immune response to this pathogenic nematode and, thus, represents a mechanism of immune evasion.<\/jats:p>","DOI":"10.4049\/jimmunol.1001920","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T03:40:35Z","timestamp":1298086835000},"page":"4295-4305","source":"Crossref","is-referenced-by-count":69,"title":["<i>Strongyloides ratti<\/i> Infection Induces Expansion of Foxp3+ Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB\/c Mice"],"prefix":"10.1093","volume":"186","author":[{"given":"Birte","family":"Blankenhaus","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}]},{"given":"Ulrike","family":"Klemm","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}]},{"given":"Marie-Luise","family":"Eschbach","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}]},{"given":"Tim","family":"Sparwasser","sequence":"additional","affiliation":[{"name":"Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research\u2014a joint venture between the Helmholtz Centre for Infection Research Braunschweig and the Hanover Medical School , 30625 Hanover ,","place":["Germany"]}]},{"given":"Jochen","family":"Huehn","sequence":"additional","affiliation":[{"name":"Experimental Immunology, Helmholtz Centre for Infection Research , 38124 Braunschweig ,","place":["Germany"]}]},{"given":"Anja A","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Institute of Pathology\/Research Center ImmunoSciences, Charit\u00e9-Campus Benjamin Franklin , 12203 Berlin ,","place":["Germany"]}]},{"given":"Christoph","family":"Loddenkemper","sequence":"additional","affiliation":[{"name":"Institute of Pathology\/Research Center ImmunoSciences, Charit\u00e9-Campus Benjamin Franklin , 12203 Berlin ,","place":["Germany"]}]},{"given":"Thomas","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}]},{"given":"Minka","family":"Breloer","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine , 20359 Hamburg ,","place":["Germany"]}]}],"member":"286","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"2025032411163023400_r1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-3024.2005.00792.x","article-title":"Immunomodulation by filarial nematodes","volume":"27","author":"Hoerauf","year":"2005","journal-title":"Parasite Immunol."},{"key":"2025032411163023400_r2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.0105-2896.2004.00191.x","article-title":"Helminth parasites\u2014masters of regulation","volume":"201","author":"Maizels","year":"2004","journal-title":"Immunol. 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