{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:51:43Z","timestamp":1768485103946,"version":"3.49.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sepsis is the third most common cause of neonatal death, with Group B Streptococcus (GBS) being the leading bacterial agent. The pathogenesis of neonatal septicemia is still unsolved. We described previously that host susceptibility to GBS infection is due to early IL-10 production. In this study, we investigated whether triggering TLR2 to produce IL-10 is a risk factor for neonatal bacterial sepsis. We observed that, in contrast to wild-type (WT) pups, neonatal TLR2-deficient mice were resistant to GBS-induced sepsis. Moreover, if IL-10 signaling were blocked in WT mice, they also were resistant to sepsis. This increased survival rate was due to an efficient recruitment of neutrophils to infected tissues that leads to bacterial clearance, thus preventing the development of sepsis. To confirm that IL-10 produced through TLR2 activation prevents neutrophil recruitment, WT pups were treated with the TLR2 agonist Pam3CSK4 prior to nebulization with the neutrophil chemotactic agent LTB4. Neutrophil recruitment into the neonatal lungs was inhibited in pups treated with Pam3CSK4. However, the migration was restored in Pam3CSK4-treated pups when IL-10 signaling was blocked (either by anti\u2013IL-10R mAb treatment or by using IL-10\u2013deficient mice). Our findings highlight that TLR2-induced IL-10 production is a key event in neonatal susceptibility to bacterial sepsis.<\/jats:p>","DOI":"10.4049\/jimmunol.1301752","type":"journal-article","created":{"date-parts":[[2013,9,28]],"date-time":"2013-09-28T05:03:48Z","timestamp":1380344628000},"page":"4759-4768","source":"Crossref","is-referenced-by-count":60,"title":["TLR2-Induced IL-10 Production Impairs Neutrophil Recruitment to Infected Tissues during Neonatal Bacterial Sepsis"],"prefix":"10.1093","volume":"191","author":[{"given":"Elva B","family":"Andrade","sequence":"first","affiliation":[{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto , 4050-313 Porto,","place":["Portugal"]},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto , 4150-180 Porto,","place":["Portugal"]}]},{"given":"Joana","family":"Alves","sequence":"additional","affiliation":[{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto , 4050-313 Porto,","place":["Portugal"]},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto , 4150-180 Porto,","place":["Portugal"]}]},{"given":"Pedro","family":"Madureira","sequence":"additional","affiliation":[{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto , 4050-313 Porto,","place":["Portugal"]},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto , 4150-180 Porto,","place":["Portugal"]}]},{"given":"Liliana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto , 4050-313 Porto,","place":["Portugal"]},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto , 4150-180 Porto,","place":["Portugal"]}]},{"given":"Ad\u00edlia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto , 4050-313 Porto,","place":["Portugal"]},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto , 4150-180 Porto,","place":["Portugal"]}]},{"given":"Anabela","family":"Cordeiro-da-Silva","sequence":"additional","affiliation":[{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto , 4150-180 Porto,","place":["Portugal"]},{"name":"Faculdade de Farm\u00e1cia da Universidade do Porto, Universidade do Porto , 4050-313 Porto,","place":["Portugal"]}]},{"given":"Margarida","family":"Correia-Neves","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho , 4710-057 Braga,","place":["Portugal"]},{"name":"Life and Health Sciences Research Institute\/3B\u2019s, Portuguese Government Associate Laboratory , 4710-057 Braga\/Guimar\u00e3es,","place":["Portugal"]}]},{"given":"Patrick","family":"Trieu-Cuot","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Biologie des Bact\u00e9ries Pathog\u00e8nes \u00e0 Gram-Positif, Centre National de la Recherche Scientifique \u00c9quipe de Recherche Labellis\u00e9e (ERL) 3526 , 75724 Paris,","place":["France"]}]},{"given":"Paula","family":"Ferreira","sequence":"additional","affiliation":[{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Universidade do Porto , 4050-313 Porto,","place":["Portugal"]},{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular, Universidade do Porto , 4150-180 Porto,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2025032405515257700_r1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri1394","article-title":"Neonatal adaptive immunity comes of age","volume":"4","author":"Adkins","year":"2004","journal-title":"Nat. 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