{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:13:26Z","timestamp":1772255606081,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is able to promote the generation of tolerogenic mature dendritic cells (mDCs) with an impaired ability to activate autoreactive T cells. These cells could represent a reliable tool for the promotion or restoration of Ag-specific tolerance through vaccination strategies, for example in type 1 diabetes patients. However, successful transfer of 1,25(OH)2D3-treated mDCs (1,25D3-mDCs) depends on the capacity of 1,25(OH)2D3 to imprint a similar tolerogenic profile in cells derived from diabetes-prone donors as from diabetes-resistant donors. In this study, we examined the impact of 1,25(OH)2D3 on the function and phenotype of mDCs originating from healthy (C57BL\/6) and diabetes-prone (NOD) mice. We show that 1,25(OH)2D3 is able to imprint a phenotypic tolerogenic profile on DCs derived from both mouse strains. Both NOD- and C57BL\/6-derived 1,25D3-mDCs decreased the proliferation and activation of autoreactive T cells in vitro, despite strain differences in the regulation of cytokine\/chemokine expression. In addition, 1,25D3-mDCs from diabetes-prone mice expanded CD25+Foxp3+ regulatory T cells and induced intracellular IL-10 production by T cells in vitro. Furthermore, 1,25D3-mDCs exhibited an intact functional migratory capacity in vivo that favors homing to the liver and pancreas of adult NOD mice. More importantly, when cotransferred with activated CD4+ T cells into NOD.SCID recipients, 1,25D3-mDCs potently dampened the proliferation of autoreactive donor T cells in the pancreatic draining lymph nodes. Altogether, these results argue for the potential of 1,25D3-mDCs to restore Ag-specific immune tolerance and arrest autoimmune disease progression in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.1302350","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T01:39:59Z","timestamp":1395711599000},"page":"4210-4220","source":"Crossref","is-referenced-by-count":109,"title":["1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice"],"prefix":"10.1093","volume":"192","author":[{"given":"Gabriela B","family":"Ferreira","sequence":"first","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Conny A","family":"Gysemans","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Jocelyne","family":"Demengeot","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Physiology, Instituto Gulbenkian de Ci\u00eancia , 2780-156 Oeiras,","place":["Portugal"]}]},{"given":"Jo\u00e3o Paulo M C M","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"An-Sofie","family":"Vanherwegen","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Lut","family":"Overbergh","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Tom L","family":"Van Belle","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Femke","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Annemieke","family":"Verstuyf","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Hannelie","family":"Korf","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]},{"given":"Chantal","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2025032404255769200_r1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s11892-012-0322-3","article-title":"Vitamin D, immune tolerance, and prevention of type 1 diabetes","volume":"12","author":"Badenhoop","year":"2012","journal-title":"Curr. 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Proteome Res."},{"key":"2025032404255769200_r5","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.4049\/jimmunol.0803345","article-title":"1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype","volume":"182","author":"Sz\u00e9les","year":"2009","journal-title":"J. Immunol."},{"key":"2025032404255769200_r6","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1073\/pnas.121172198","article-title":"Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo","volume":"98","author":"Griffin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. 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