{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:40:44Z","timestamp":1769640044040,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dual oxidase 1 (Duox1) is the NADPH oxidase responsible for the H2O2 gradient formed in tissues after injury to trigger the early recruitment of leukocytes. Little is known about the signals that modulate H2O2 release from DUOX1 and whether the H2O2 gradient can orchestrate the inflammatory response in vivo. In this study, we report on a dominant-negative form of zebrafish Duox1 that is able to inhibit endogenous Duox1 activity, H2O2 release and leukocyte recruitment after tissue injury, with none of the side effects associated with morpholino-mediated Duox1 knockdown. Using this specific tool, we found that ATP release following tissue injury activates purinergic P2Y receptors, and modulates Duox1 activity through phospholipase C (PLC) and intracellular calcium signaling in vivo. Furthermore, Duox1-derived H2O2 is able to trigger the NF-\u03baB inflammatory signaling pathway. These data reveal that extracellular ATP acting as an early danger signal is responsible for the activation of Duox1 via a P2YR\/PLC\/Ca2+ signaling pathway and the production of H2O2, which, in turn, is able to modulate in vivo not only the early recruitment of leukocytes to the wound but also the inflammatory response through activation of the NF-\u03baB signaling pathway.<\/jats:p>","DOI":"10.4049\/jimmunol.1302902","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T05:10:54Z","timestamp":1400562654000},"page":"5710-5719","source":"Crossref","is-referenced-by-count":76,"title":["ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1\u2013Derived H2O2 Production and NF-\u03baB Activation"],"prefix":"10.1093","volume":"192","author":[{"given":"Sofia","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Carlota Saldanha, Instituto de Medicina Molecular , 1649-028 Lisbon,","place":["Portugal"]},{"name":"Instituto de Bioqu\u00edmica, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon,","place":["Portugal"]},{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia , 30100 Murcia,","place":["Spain"]}]},{"given":"Azucena","family":"L\u00f3pez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia , 30100 Murcia,","place":["Spain"]},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria , 30120 Murcia,","place":["Spain"]}]},{"given":"Sergio","family":"Candel","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia , 30100 Murcia,","place":["Spain"]},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria , 30120 Murcia,","place":["Spain"]}]},{"given":"Pablo","family":"Pelegr\u00edn","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria , 30120 Murcia,","place":["Spain"]},{"name":"Unidad de Inflamaci\u00f3n y Cirug\u00eda Experimental, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en el \u00c1rea Tem\u00e1tica de Enfermedades Hep\u00e1ticas y Digestivas, Hospital Universitario Virgen de la Hospital Universitario Virgen de la Arrixaca , 30120 Murcia,","place":["Spain"]}]},{"given":"\u00c2ngelo","family":"Calado","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Carlota Saldanha, Instituto de Medicina Molecular , 1649-028 Lisbon,","place":["Portugal"]},{"name":"Instituto de Bioqu\u00edmica, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon,","place":["Portugal"]}]},{"given":"Victoriano","family":"Mulero","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia , 30100 Murcia,","place":["Spain"]},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria , 30120 Murcia,","place":["Spain"]}]}],"member":"286","published-online":{"date-parts":[[2014,6,15]]},"reference":[{"key":"2025032404355988500_r1","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1111\/j.1742-4658.2008.06488.x","article-title":"Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species","volume":"275","author":"Sumimoto","year":"2008","journal-title":"FEBS J."},{"key":"2025032404355988500_r2","doi-asserted-by":"crossref","first-page":"23227","DOI":"10.1074\/jbc.M000916200","article-title":"Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family","volume":"275","author":"De Deken","year":"2000","journal-title":"J. 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