{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:48:04Z","timestamp":1773564484321,"version":"3.50.1"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":3810,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tuberculosis, caused by the intracellular bacterium Mycobacterium tuberculosis, currently causes \u223c1.4 million deaths per year, and it therefore remains a leading global health problem. The immune response during tuberculosis remains incompletely understood, particularly regarding immune factors that are harmful rather than protective to the host. Overproduction of the type I IFN family of cytokines is associated with exacerbated tuberculosis in both mouse models and in humans, although the mechanisms by which type I IFN promotes disease are not well understood. We have investigated the effect of type I IFN on M. tuberculosis\u2013infected macrophages and found that production of host-protective cytokines such as TNF-\u03b1, IL-12, and IL-1\u03b2 is inhibited by exogenous type I IFN, whereas production of immunosuppressive IL-10 is promoted in an IL-27\u2013independent manner. Furthermore, much of the ability of type I IFN to inhibit cytokine production was mediated by IL-10. Additionally, type I IFN compromised macrophage activation by the lymphoid immune response through severely disrupting responsiveness to IFN-\u03b3, including M. tuberculosis killing. These findings describe important mechanisms by which type I IFN inhibits the immune response during tuberculosis.<\/jats:p>","DOI":"10.4049\/jimmunol.1401088","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T10:42:39Z","timestamp":1409827359000},"page":"3600-3612","source":"Crossref","is-referenced-by-count":175,"title":["Type I IFN Induces IL-10 Production in an IL-27\u2013Independent Manner and Blocks Responsiveness to IFN-\u03b3 for Production of IL-12 and Bacterial Killing in\n                    <i>Mycobacterium tuberculosis<\/i>\n                    \u2013Infected Macrophages"],"prefix":"10.1093","volume":"193","author":[{"given":"Finlay W","family":"McNab","sequence":"first","affiliation":[{"name":"Division of Immunoregulation, Medical Research Council National Institute for Medical Research , London NW7 1AA ,","place":["United Kingdom"]}]},{"given":"John","family":"Ewbank","sequence":"additional","affiliation":[{"name":"Division of Immunoregulation, Medical Research Council National Institute for Medical Research , London NW7 1AA ,","place":["United Kingdom"]}]},{"given":"Ashleigh","family":"Howes","sequence":"additional","affiliation":[{"name":"Division of Immunoregulation, Medical Research Council National Institute for Medical Research , London NW7 1AA ,","place":["United Kingdom"]}]},{"given":"Lucia","family":"Moreira-Teixeira","sequence":"additional","affiliation":[{"name":"Division of Immunoregulation, Medical Research Council National Institute for Medical Research , London NW7 1AA ,","place":["United Kingdom"]},{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho , 4710-057 Braga ,","place":["Portugal"]},{"name":"Life and Health Sciences Research Institute and Biomaterials, Biodegradables and Biomimetics Research Group, Portugal Government Associate Laboratory , 4710-057 Braga\/Guimar\u00e3es ,","place":["Portugal"]}]},{"given":"Anna","family":"Martirosyan","sequence":"additional","affiliation":[{"name":"Division of Immunoregulation, Medical Research Council National Institute for Medical Research , London NW7 1AA ,","place":["United Kingdom"]}]},{"given":"Nico","family":"Ghilardi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genentech, Inc. , South San Francisco, CA 94080"}]},{"given":"Margarida","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho , 4710-057 Braga ,","place":["Portugal"]},{"name":"Life and Health Sciences Research Institute and Biomaterials, Biodegradables and Biomimetics Research Group, Portugal Government Associate Laboratory , 4710-057 Braga\/Guimar\u00e3es ,","place":["Portugal"]}]},{"given":"Anne","family":"O\u2019Garra","sequence":"additional","affiliation":[{"name":"Division of Immunoregulation, Medical Research Council National Institute for Medical Research , London NW7 1AA ,","place":["United Kingdom"]}]}],"member":"286","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"2025030707383918600_r1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.021908.132703","article-title":"Cell-mediated immune responses in tuberculosis","volume":"27","author":"Cooper","year":"2009","journal-title":"Annu. 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