{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:21:54Z","timestamp":1768623714118,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cryptococcus neoformans is a fungal pathogen with a unique intracellular pathogenic strategy that includes nonlytic exocytosis, a phenomenon whereby fungal cells are expunged from macrophages without lysing the host cell. The exact mechanism and specific proteins involved in this process have yet to be completely defined. Using murine macrophages deficient in the membrane phospholipid binding protein, annexin A2 (ANXA2), we observed a significant decrease in both phagocytosis of yeast cells and the frequency of nonlytic exocytosis. Cryptococcal cells isolated from Anxa2-deficient (Anxa2\u2212\/\u2212) bone marrow\u2013derived macrophages and lung parenchyma displayed significantly larger capsules than those isolated from wild-type macrophages and tissues. Concomitantly, we observed significant differences in the amount of reactive oxygen species produced between Anxa2\u2212\/\u2212 and Anxa2+\/+ macrophages. Despite comparable fungal burden, Anxa2\u2212\/\u2212 mice died more rapidly than wild-type mice when infected with C. neoformans, and Anxa2\u2212\/\u2212 mice exhibited enhanced inflammatory responses, suggesting that the reduced survival reflected greater immune-mediated damage. Together, these findings suggest a role for ANXA2 in the control of cryptococcal infection, macrophage function, and fungal morphology.<\/jats:p>","DOI":"10.4049\/jimmunol.1501855","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T02:54:47Z","timestamp":1467428087000},"page":"1252-1261","source":"Crossref","is-referenced-by-count":41,"title":["The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of <i>Cryptococcus neoformans<\/i> and Impacts Survival in Fungal Infection"],"prefix":"10.1093","volume":"197","author":[{"given":"Sabriya","family":"Stukes","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-3031","authenticated-orcid":false,"given":"Carolina","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"},{"name":"Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-4861","authenticated-orcid":false,"given":"Johanna","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"}]},{"given":"Anne E","family":"Jedlicka","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-4356","authenticated-orcid":false,"given":"Katherine A","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Weill Cornell Medicine , New York, NY 10065"},{"name":"Department of Cell and Developmental Biology, Weill Cornell Medicine , New York, NY 10065"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-9167","authenticated-orcid":false,"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"},{"name":"Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}]}],"member":"286","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"2025030617472976500_r1","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/IAI.68.7.4225-4237.2000","article-title":"Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection","volume":"68","author":"Feldmesser","year":"2000","journal-title":"Infect. 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