{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:57:30Z","timestamp":1776920250134,"version":"3.51.2"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\u03b3\u03b4 T lymphocytes are programmed into distinct IFN-\u03b3\u2013producing CD27+ (\u03b3\u03b427+) and IL-17\u2013producing CD27\u2212 (\u03b3\u03b427\u2212) subsets that play key roles in protective or pathogenic immune responses. Although the signature cytokines are shared with their \u03b1\u03b2 Th1 (for \u03b3\u03b427+) and Th17 (for \u03b3\u03b427\u2212) cell counterparts, we dissect in this study similarities and differences in the transcriptional requirements of murine effector \u03b3\u03b427+, \u03b3\u03b427\u2212CCR6\u2212, and \u03b3\u03b427\u2212CCR6+ \u03b3\u03b4 T cell subsets and \u03b1\u03b2 T cells. We found they share dependence on the master transcription factors T-bet and ROR\u03b3t for IFN-\u03b3 and IL-17 production, respectively. However, Eomes is fully dispensable for IFN-\u03b3 production by \u03b3\u03b4 T cells. Furthermore, the Th17 cell auxiliary transcription factors ROR\u03b1 and BATF are not required for IL-17 production by \u03b3\u03b427\u2212 cell subsets. We also show that \u03b3\u03b427\u2212 (but not \u03b3\u03b427+) cells become polyfunctional upon IL-1\u03b2 plus IL-23 stimulation, cosecreting IL-17A, IL-17F, IL-22, GM-CSF, and IFN-\u03b3. Collectively, our in vitro and in vivo data firmly establish the molecular segregation between \u03b3\u03b427+ and \u03b3\u03b427\u2212 T cell subsets and provide novel insight on the nonoverlapping transcriptional networks that control the differentiation of effector \u03b3\u03b4 versus \u03b1\u03b2 T cell subsets.<\/jats:p>","DOI":"10.4049\/jimmunol.1501921","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T03:50:22Z","timestamp":1458359422000},"page":"3642-3652","source":"Crossref","is-referenced-by-count":74,"title":["Effector \u03b3\u03b4 T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-4990","authenticated-orcid":false,"given":"Joana","family":"Barros-Martins","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4460-8195","authenticated-orcid":false,"given":"Nina","family":"Schmolka","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]}]},{"given":"Diana","family":"Fontinha","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-4963","authenticated-orcid":false,"given":"Marta","family":"Pires de Miranda","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6982-9253","authenticated-orcid":false,"given":"J Pedro","family":"Simas","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]}]},{"given":"Ingrid","family":"Brok","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-932X","authenticated-orcid":false,"given":"Cristina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory for Lymphocyte Signalling and Development, Babraham Institute , Cambridge CB22 3AT ,","place":["United Kingdom"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-9562","authenticated-orcid":false,"given":"Marc","family":"Veldhoen","sequence":"additional","affiliation":[{"name":"Laboratory for Lymphocyte Signalling and Development, Babraham Institute , Cambridge CB22 3AT ,","place":["United Kingdom"]}]},{"given":"Bruno","family":"Silva-Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]},{"name":"Instituto Gulbenkian de Ci\u00eancia , 2781-901 Oeiras ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-4739","authenticated-orcid":false,"given":"Karine","family":"Serre","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon ,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"2025030702162774700_r1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.2009.05133.x","article-title":"Th1 and Th17 cells: adversaries and collaborators","volume":"1183","author":"Damsker","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025030702162774700_r2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"2025030702162774700_r3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity","volume":"31","author":"Sutton","year":"2009","journal-title":"Immunity"},{"key":"2025030702162774700_r4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.immuni.2010.08.013","article-title":"\u03b3\u03b4 T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism","volume":"33","author":"Petermann","year":"2010","journal-title":"Immunity"},{"key":"2025030702162774700_r5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2009.08.006","article-title":"Gammadelta T cells and the lymphoid stress-surveillance response","volume":"31","author":"Hayday","year":"2009","journal-title":"Immunity"},{"key":"2025030702162774700_r6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations (*)","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"2025030702162774700_r7","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.4049\/jimmunol.1004021","article-title":"Cutting edge: generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ \u03b3\u03b4 T cells","volume":"186","author":"Do","year":"2011","journal-title":"J. Immunol."},{"key":"2025030702162774700_r8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.immuni.2010.10.014","article-title":"T regulatory cells maintain intestinal homeostasis by suppressing \u03b3\u03b4 T cells","volume":"33","author":"Park","year":"2010","journal-title":"Immunity"},{"key":"2025030702162774700_r9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.immuni.2008.04.022","article-title":"Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma","volume":"29","author":"Jensen","year":"2008","journal-title":"Immunity"},{"key":"2025030702162774700_r10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ni.1717","article-title":"CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ni.2773","article-title":"Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness","volume":"15","author":"Wencker","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r12","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1126\/science.1090148","article-title":"Control of effector CD8+ T cell function by the transcription factor Eomesodermin","volume":"302","author":"Pearce","year":"2003","journal-title":"Science"},{"key":"2025030702162774700_r13","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/eji.201242872","article-title":"Emerging new roles of Th17 cells","volume":"42","author":"Kuchroo","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2025030702162774700_r14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni.1993","article-title":"Fate mapping of IL-17-producing T cells in inflammatory responses","volume":"12","author":"Hirota","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2008.11.005","article-title":"Late developmental plasticity in the T helper 17 lineage","volume":"30","author":"Lee","year":"2009","journal-title":"Immunity"},{"key":"2025030702162774700_r16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.immuni.2011.09.019","article-title":"Th17 cells are long lived and retain a stem cell-like molecular signature","volume":"35","author":"Muranski","year":"2011","journal-title":"Immunity"},{"key":"2025030702162774700_r17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.immuni.2014.01.002","article-title":"The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-\u03b3-producing T helper 17 cells","volume":"40","author":"Wang","year":"2014","journal-title":"Immunity"},{"key":"2025030702162774700_r18","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.4049\/jimmunol.1203172","article-title":"Cutting edge: the pathogenicity of IFN-\u03b3-producing Th17 cells is independent of T-bet","volume":"190","author":"Duhen","year":"2013","journal-title":"J. Immunol."},{"key":"2025030702162774700_r19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1172\/JCI37865","article-title":"Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD\/SCID recipient mice","volume":"119","author":"Bending","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2025030702162774700_r20","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni.2416","article-title":"Induction and molecular signature of pathogenic TH17 cells","volume":"13","author":"Lee","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r21","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.20082584","article-title":"T-bet is essential for encephalitogenicity of both Th1 and Th17 cells","volume":"206","author":"Yang","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030702162774700_r22","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1002\/eji.201343723","article-title":"Highly polarized Th17 cells induce EAE via a T-bet independent mechanism","volume":"43","author":"Grifka-Walk","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"2025030702162774700_r23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-020711-075058","article-title":"Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity","volume":"30","author":"Kanno","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"2025030702162774700_r24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2012.09.016","article-title":"A validated regulatory network for Th17 cell specification","volume":"151","author":"Ciofani","year":"2012","journal-title":"Cell"},{"key":"2025030702162774700_r25","doi-asserted-by":"crossref","first-page":"20846","DOI":"10.1073\/pnas.0809077106","article-title":"IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype","volume":"105","author":"Huber","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702162774700_r26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ni1500","article-title":"The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4","volume":"8","author":"Br\u00fcstle","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature08114","article-title":"The AP-1 transcription factor Batf controls T(H)17 differentiation","volume":"460","author":"Schraml","year":"2009","journal-title":"Nature"},{"key":"2025030702162774700_r28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"2025030702162774700_r29","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1002\/eji.201142155","article-title":"Unlike \u03b1\u03b2 T cells, \u03b3\u03b4 T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22","volume":"42","author":"Raifer","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2025030702162774700_r30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2011.02.019","article-title":"RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in \u03b3\u03b4 T cells","volume":"34","author":"Powolny-Budnicka","year":"2011","journal-title":"Immunity"},{"key":"2025030702162774700_r31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2172-14-16","article-title":"BATF regulates the development and function of IL-17 producing iNKT cells","volume":"14","author":"Jordan-Williams","year":"2013","journal-title":"BMC Immunol."},{"key":"2025030702162774700_r32","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1002\/eji.200939922","article-title":"CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells","volume":"39","author":"Haas","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"2025030702162774700_r33","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.immuni.2009.06.020","article-title":"Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals","volume":"31","author":"Martin","year":"2009","journal-title":"Immunity"},{"key":"2025030702162774700_r34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni.2702","article-title":"Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory \u03b3\u03b4 T cell subsets","volume":"14","author":"Schmolka","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2013.06.015","article-title":"\u03b3\u03b4 T cells exhibit multifunctional and protective memory in intestinal tissues","volume":"39","author":"Sheridan","year":"2013","journal-title":"Immunity"},{"key":"2025030702162774700_r36","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.4049\/jimmunol.1002283","article-title":"Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-\u03b3- or IL-17-producing \u03b3\u03b4 T cells upon infection","volume":"185","author":"Ribot","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702162774700_r37","doi-asserted-by":"crossref","first-page":"17549","DOI":"10.1073\/pnas.1204327109","article-title":"Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing \u03b3\u03b4 cells","volume":"109","author":"Michel","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702162774700_r38","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.immuni.2012.06.011","article-title":"\u03b3\u03b4 T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response","volume":"37","author":"Zeng","year":"2012","journal-title":"Immunity"},{"key":"2025030702162774700_r39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4049\/jimmunol.1502082","article-title":"Differential responsiveness of innate-like IL-17- and IFN-\u03b3-producing \u03b3\u03b4 T cells to homeostatic cytokines","volume":"196","author":"Corpuz","year":"2016","journal-title":"J. Immunol."},{"key":"2025030702162774700_r40","doi-asserted-by":"crossref","first-page":"e39750","DOI":"10.1371\/journal.pone.0039750","article-title":"Marking and quantifying IL-17A-producing cells in vivo","volume":"7","author":"Price","year":"2012","journal-title":"PLoS One"},{"key":"2025030702162774700_r41","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.4049\/jimmunol.168.4.1566","article-title":"T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells","volume":"168","author":"Yin","year":"2002","journal-title":"J. Immunol."},{"key":"2025030702162774700_r42","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.4049\/jimmunol.178.5.2730","article-title":"Epigenetic and transcriptional programs lead to default IFN-\u03b3 production by gammadelta T cells","volume":"178","author":"Chen","year":"2007","journal-title":"J. Immunol."},{"key":"2025030702162774700_r43","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1084\/jem.20122097","article-title":"Distinct requirements for T-bet in gut innate lymphoid cells","volume":"209","author":"Scium\u00e9","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030702162774700_r44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature11813","article-title":"A T-bet gradient controls the fate and function of CCR6-ROR\u03b3t+ innate lymphoid cells","volume":"494","author":"Klose","year":"2013","journal-title":"Nature"},{"key":"2025030702162774700_r45","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.immuni.2012.08.024","article-title":"Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria","volume":"37","author":"Basu","year":"2012","journal-title":"Immunity"},{"key":"2025030702162774700_r46","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1084\/jem.185.11.1969","article-title":"T cell receptor-gamma\/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis","volume":"185","author":"Sciammas","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025030702162774700_r47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ni.1969","article-title":"T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding ROR\u03b3t","volume":"12","author":"Lazarevic","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r48","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.4049\/jimmunol.0803821","article-title":"T-bet inhibits the in vivo differentiation of parasite-specific CD4+ Th17 cells in a T cell-intrinsic manner","volume":"182","author":"Guo","year":"2009","journal-title":"J. Immunol."},{"key":"2025030702162774700_r49","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4049\/jimmunol.0903767","article-title":"Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin","volume":"185","author":"He","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702162774700_r50","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1182\/blood-2011-02-334995","article-title":"Notch-Hes1 pathway is required for the development of IL-17-producing \u03b3\u03b4 T cells","volume":"118","author":"Shibata","year":"2011","journal-title":"Blood"},{"key":"2025030702162774700_r51","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"2025030702162774700_r52","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.20080034","article-title":"In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells","volume":"205","author":"Lochner","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025030702162774700_r53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/imr.12208","article-title":"Transcriptional and epigenetic networks of helper T and innate lymphoid cells","volume":"261","author":"Shih","year":"2014","journal-title":"Immunol. Rev."},{"key":"2025030702162774700_r54","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/ni.2587","article-title":"Identification of transcriptional regulators in the mouse immune system","volume":"14","author":"Jojic","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r55","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.immuni.2013.01.010","article-title":"A network of high-mobility group box transcription factors programs innate interleukin-17 production","volume":"38","author":"Malhotra","year":"2013","journal-title":"Immunity"},{"key":"2025030702162774700_r56","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/ni.2585","article-title":"Deficiency in IL-17-committed V\u03b34(+) \u03b3\u03b4 T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis","volume":"14","author":"Gray","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025030702162774700_r57","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cellimm.2015.03.007","article-title":"Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?","volume":"296","author":"Zarin","year":"2015","journal-title":"Cell. Immunol."},{"key":"2025030702162774700_r58","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.0903539","article-title":"Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism","volume":"184","author":"Do","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702162774700_r59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chom.2010.01.005","article-title":"Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma\/delta T cells","volume":"7","author":"Duan","year":"2010","journal-title":"Cell Host Microbe"},{"key":"2025030702162774700_r60","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/icb.2013.70","article-title":"Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and \u03b3\u03b4 T cells","volume":"92","author":"Do","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"2025030702162774700_r61","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing \u03b3\u03b4 T cells in skin inflammation","volume":"35","author":"Cai","year":"2011","journal-title":"Immunity"},{"key":"2025030702162774700_r62","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1172\/JCI61862","article-title":"Ror\u03b3t+ innate lymphocytes and \u03b3\u03b4 T cells initiate psoriasiform plaque formation in mice","volume":"122","author":"Pantelyushin","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2025030702162774700_r63","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.4049\/jimmunol.1300626","article-title":"IL-23 receptor expression on \u03b3\u03b4 T cells correlates with their enhancing or suppressive effects on autoreactive T cells in experimental autoimmune uveitis","volume":"191","author":"Liang","year":"2013","journal-title":"J. Immunol."},{"key":"2025030702162774700_r64","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1158\/0008-5472.CAN-13-2534","article-title":"IL-17A produced by \u03b3\u03b4 T cells promotes tumor growth in hepatocellular carcinoma","volume":"74","author":"Ma","year":"2014","journal-title":"Cancer Res."},{"key":"2025030702162774700_r65","doi-asserted-by":"crossref","first-page":"E3562","DOI":"10.1073\/pnas.1403424111","article-title":"Murine CD27(-) V\u03b36(+) \u03b3\u03b4 T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages","volume":"111","author":"Rei","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702162774700_r66","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"2025030702162774700_r67","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.immuni.2014.03.013","article-title":"\u03b3\u03b4T17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer","volume":"40","author":"Wu","year":"2014","journal-title":"Immunity"},{"key":"2025030702162774700_r68","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human Th17 cells","volume":"204","author":"Annunziato","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025030702162774700_r69","doi-asserted-by":"crossref","first-page":"679","DOI":"10.4049\/jimmunol.1000366","article-title":"Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage","volume":"185","author":"Boniface","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702162774700_r70","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.4049\/jimmunol.1500375","article-title":"Adaptive immune-like \u03b3\/\u03b4 T lymphocytes share many common features with their \u03b1\/\u03b2 T cell counterparts","volume":"195","author":"Lombes","year":"2015","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/9\/3642\/62255726\/1501921.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/9\/3642\/62255726\/1501921.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T02:36:46Z","timestamp":1741315006000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/196\/9\/3642\/7974432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,1]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1501921","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,5]]},"published":{"date-parts":[[2016,5,1]]}}}