{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:05:54Z","timestamp":1762459554100,"version":"build-2065373602"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It has been shown that dominant tolerance, namely in transplantation, requires Foxp3+ regulatory T cells. Although most tolerance-inducing regimens rely on regulatory T cells, we found that induction of tolerance to proteins in aluminum hydroxide can be achieved in Foxp3-deficient mice using nondepleting anti-CD4 Abs. This type of tolerance is Ag specific, and tolerant mice retain immune competence to respond to unrelated Ags. We demonstrated with chicken OVA\u2013specific TCR-transgenic mice that the same tolerizing protocol (CD4 blockade) and the same target Ag (OVA) achieves Foxp3-dependent transplantation tolerance to OVA-expressing skin grafts, but Foxp3-independent tolerance when the Ag is provided as OVA\u2013aluminum hydroxide. In the latter case, we found that tolerance induction triggered recessive mechanisms leading to elimination of effector cells and, simultaneously, a dominant mechanism associated with the emergence of an anergic and regulatory CTLA-4+IL-2lowFoxp3\u2212 T cell population, where the tolerance state is IL-10 dependent. Such Foxp3-independent mechanisms can improve the efficacy of tolerance-inducing protocols.<\/jats:p>","DOI":"10.4049\/jimmunol.1601886","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T16:15:25Z","timestamp":1511367325000},"page":"101-109","source":"Crossref","is-referenced-by-count":3,"title":["Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance"],"prefix":"10.1093","volume":"200","author":[{"given":"Ana","family":"Agua-Doce","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon,","place":["Portugal"]},{"name":"Instituto Gulbenkian de Ci\u00eancia , 2780-156 Oeiras,","place":["Portugal"]}]},{"given":"Marta","family":"Caridade","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon,","place":["Portugal"]},{"name":"Instituto Gulbenkian de Ci\u00eancia , 2780-156 Oeiras,","place":["Portugal"]}]},{"given":"Vanessa G","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon,","place":["Portugal"]},{"name":"Instituto Gulbenkian de Ci\u00eancia , 2780-156 Oeiras,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-4308","authenticated-orcid":false,"given":"Lisa","family":"Bergman","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2780-156 Oeiras,","place":["Portugal"]}]},{"given":"Maria C","family":"Lafaille","sequence":"additional","affiliation":[{"name":"Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine , New York, NY 10016"}]},{"given":"Juan J","family":"Lafaille","sequence":"additional","affiliation":[{"name":"Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine , New York, NY 10016"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4761-614X","authenticated-orcid":false,"given":"Jocelyne","family":"Demengeot","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia , 2780-156 Oeiras,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-8500","authenticated-orcid":false,"given":"Luis","family":"Graca","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , 1649-028 Lisbon,","place":["Portugal"]},{"name":"Instituto Gulbenkian de Ci\u00eancia , 2780-156 Oeiras,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2025030610003438700_r1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-065X.2009.00776.x","article-title":"Translating costimulation blockade to the clinic: lessons learned from three pathways","volume":"229","author":"Ford","year":"2009","journal-title":"Immunol. 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