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This implies the existence of an alternate receptor, whose identity we sought to pinpoint. We found that blockage of integrin \u03b21 selectively hampered binding of mIgG3 to macrophages and mIgG3-mediated phagocytosis. Manganese, an integrin activator, increased mIgG3 binding to macrophages. Blockage of Fc\u03b3RI or Itgb1 inhibited binding of different mIgG3 Abs to variable extents. Our results are consistent with the notion that Itgb1 functions as part of an IgG receptor complex. Given the more ancient origin of integrins in comparison with Fc\u03b3R, this observation could have far-ranging implications for our understanding of the evolution of Ab-mediated immunity as well as in immunity to microorganisms, pathogenesis of autoimmune diseases, and Ab engineering.<\/jats:p>","DOI":"10.4049\/jimmunol.1701795","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T18:45:57Z","timestamp":1553107557000},"page":"2782-2794","source":"Crossref","is-referenced-by-count":15,"title":["Integrin \u03b21 Promotes the Interaction of Murine IgG3 with Effector Cells"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-6129","authenticated-orcid":false,"given":"Carolyn Saylor","family":"Hawk","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"}]},{"given":"Carolina","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-4672","authenticated-orcid":false,"given":"Diane Sthefany Lima","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF 70910-900 ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-0230","authenticated-orcid":false,"given":"Verenice","family":"Paredes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Bras\u00edlia , Bras\u00edlia, DF 70910-900 ,","place":["Brazil"]},{"name":"Karan Technologies Research and Development , Bras\u00edlia, DF 70632-200 ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8160-7784","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Faculty of Ceil\u00e2ndia, University of Bras\u00edlia , Bras\u00edlia, DF 72220-275 ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-5300","authenticated-orcid":false,"given":"Anam\u00e9lia Lorenzetti","family":"Bocca","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF 70910-900 ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0809-1475","authenticated-orcid":false,"given":"Anan\u00e9sia","family":"Correa dos Santos","sequence":"additional","affiliation":[{"name":"Karan Technologies Research and Development , Bras\u00edlia, DF 70632-200 ,","place":["Brazil"]}]},{"given":"Victoria","family":"Rusakova","sequence":"additional","affiliation":[{"name":"MilliporeSigma , St. Louis, MO 63103"}]},{"given":"Heather","family":"Holemon","sequence":"additional","affiliation":[{"name":"MilliporeSigma , St. Louis, MO 63103"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-9363","authenticated-orcid":false,"given":"Ildinete","family":"Silva-Pereira","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF 70910-900 ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-6853","authenticated-orcid":false,"given":"Maria Sueli Soares","family":"Felipe","sequence":"additional","affiliation":[{"name":"Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Bras\u00edlia , Bras\u00edlia, DF 70790-160 ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4279-9343","authenticated-orcid":false,"given":"Hideo","family":"Yagita","sequence":"additional","affiliation":[{"name":"Department of Immunology, Juntendo University School of Medicine , Tokyo 113-8421 ,","place":["Japan"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-5835","authenticated-orcid":false,"given":"Andr\u00e9 Moraes","family":"Nicola","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Bras\u00edlia , Bras\u00edlia, DF 70910-900 ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-9167","authenticated-orcid":false,"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}]}],"member":"286","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"2025030417561755700_r1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(06)91001-3","article-title":"A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens","volume":"91","author":"Casadevall","year":"2006","journal-title":"Adv. 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