{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:02:59Z","timestamp":1774976579641,"version":"3.50.1"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004963","name":"European Community\u2019s Seventh Framework Programme","doi-asserted-by":"publisher","award":["602773"],"award-info":[{"award-number":["602773"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"F\u00e9d\u00e9ration de Recherche M\u00e9dicale","award":["FRM: SPF20160936115"],"award-info":[{"award-number":["FRM: SPF20160936115"]}]},{"name":"Infect-Era","award":["FP7"],"award-info":[{"award-number":["FP7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leishmaniases are neglected tropical diseases. The treatment of leishmaniasis relies exclusively on chemotherapy including amphotericin B (AmB), miltefosine (hexadecylphosphocholine), and pentamidine. Besides the fact that these molecules are harmful for patients, little is known about the impact of such antileishmanial drugs on primary human cells in relation to immune function. The present study demonstrates that all antileishmanial drugs inhibit CD4 and CD8 T cell proliferation at the doses that are not related to increased cell death. Our results highlight that antileishmanial drugs have an impact on monocytes by altering the expression of IL-12 induced by LPS, whereas only AmB induced IL-10 secretion; both cytokines are essential in regulating Th1 cell\u2013mediated immunity. Interestingly, IL-12 and anti\u2013IL-10 Abs improved T cell proliferation inhibited by AmB. Furthermore, our results show that in contrast to hexadecylphosphocholine and pentamidine, AmB induced gene expression of the inflammasome pathway. Thus, AmB induced IL-1\u03b2 and IL-18 secretions, which are reduced by specific inhibitors of caspase activation (Q-VD) and NLRP3 activation (MCC950). Our results reveal previously underestimated effects of antileishmanial drugs on primary human cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1900590","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T20:25:14Z","timestamp":1583353514000},"page":"1869-1880","source":"Crossref","is-referenced-by-count":15,"title":["Antileishmanial Drugs Modulate IL-12 Expression and Inflammasome Activation in Primary Human Cells"],"prefix":"10.1093","volume":"204","author":[{"given":"Sonia","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"INSERM-U1124, Paris University , 75006 Paris ,","place":["France"]}]},{"given":"Vasco","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"INSERM-U1124, Paris University , 75006 Paris ,","place":["France"]}]},{"given":"Sarah","family":"Pemberton","sequence":"additional","affiliation":[{"name":"INSERM-U1124, Paris University , 75006 Paris ,","place":["France"]},{"name":"Photeomix , 93160 Noisy Le Grand ,","place":["France"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1892-5250","authenticated-orcid":false,"given":"Mireille","family":"Laforge","sequence":"additional","affiliation":[{"name":"INSERM-U1124, Paris University , 75006 Paris ,","place":["France"]}]},{"given":"Yasmina","family":"Fortier","sequence":"additional","affiliation":[{"name":"INSERM-U1124, Paris University , 75006 Paris ,","place":["France"]}]},{"given":"Anabela","family":"Cordeiro-da-Silva","sequence":"additional","affiliation":[{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , 4200-135 Porto ,","place":["Portugal"]},{"name":"Instituto de Biologia Molecular e Celular da Universidade do Porto , 450-313 Porto ,","place":["Portugal"]},{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto , 450-313 Porto ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-8222","authenticated-orcid":false,"given":"Jane","family":"MacDougall","sequence":"additional","affiliation":[{"name":"Photeomix , 93160 Noisy Le Grand ,","place":["France"]}]},{"given":"J\u00e9r\u00f4me","family":"Estaquier","sequence":"additional","affiliation":[{"name":"INSERM-U1124, Paris University , 75006 Paris ,","place":["France"]},{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Universit\u00e9 Laval , Quebec City, Quebec G1V 4G2 ,","place":["Canada"]}]}],"member":"286","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"2025030417511268900_r1","volume-title":"Leishmaniasis","author":"World Health Organization","year":"2019"},{"key":"2025030417511268900_r2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13071-016-1412-x","article-title":"Regulation of immunity during visceral Leishmania infection","volume":"9","author":"Rodrigues","year":"2016","journal-title":"Parasit. 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