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The FGF signal pathways are the RAS\/MAP kinase pathway, PI3 kinase\/AKT pathway, and PLC\u03b3 pathway, among which the RAS\/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. Future applications of FGFs are expected when the biological functions of FGFs are potentiated through the appropriate use of delivery systems and scaffolds. This review will introduce the biology and cellular functions of FGFs and deal with the biomaterials based delivery systems and their current applications for the regeneration of tissues, including skin, blood vessel, muscle, adipose, tendon\/ligament, cartilage, bone, tooth, and nerve tissues.<\/jats:p>","DOI":"10.4061\/2010\/218142","type":"journal-article","created":{"date-parts":[[2010,11,7]],"date-time":"2010-11-07T12:33:27Z","timestamp":1289133207000},"source":"Crossref","is-referenced-by-count":553,"title":["Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration"],"prefix":"10.1177","volume":"1","author":[{"given":"Ye-Rang","family":"Yun","sequence":"first","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Eun","family":"Won","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea"},{"name":"Department of Nanobiomedical Science and WCU Research Center, Dankook University Graduate School, Cheonan 330-714, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyi","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonmo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyejin","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hyeog","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Inha University School of Medicine, Incheon 400-712, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ueon Sang","family":"Shin","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea"},{"name":"Department of Nanobiomedical Science and WCU Research Center, Dankook University Graduate School, Cheonan 330-714, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea"},{"name":"Department of Nanobiomedical Science and WCU Research Center, Dankook University Graduate School, Cheonan 330-714, Republic of Korea"},{"name":"Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"bibr1-2010_218142","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493529"},{"key":"bibr2-2010_218142","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.12.053"},{"key":"bibr3-2010_218142","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.41"},{"key":"bibr4-2010_218142","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1203"},{"key":"bibr5-2010_218142","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.02.001"},{"key":"bibr6-2010_218142","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070066"},{"key":"bibr7-2010_218142","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.11.019"},{"key":"bibr8-2010_218142","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.03.012"},{"key":"bibr9-2010_218142","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.002"},{"issue":"3","key":"bibr10-2010_218142","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-2-3-reviews3005","volume":"2","author":"Ornitz D. 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