{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:21:14Z","timestamp":1695482474672},"reference-count":32,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Hungarian Ministry of Health","award":["T 49589","T 73430"],"award-info":[{"award-number":["T 49589","T 73430"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmune Diseases"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Controversial observations have been published on the association of the cytotoxic T lymphocyte associated antigen gene's variants with rheumatoid arthritis (RA). After genotyping 428 patients and 230 matched controls, the prevalence of the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>CT<\/mml:mtext><mml:msup><mml:mrow><mml:mn>60<\/mml:mn><\/mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>G allele was more frequent in RF- and\/or anti-CCP-seropositive RApatients, compared to the healthy controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>). Regression analysis revealed that the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:msup><mml:mrow><mml:mtext>CT60<\/mml:mtext><\/mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>G allele is a possible predisposing factor for RA in these subgroups. No accumulation of the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>+<\/mml:mo><mml:msup><mml:mrow><mml:mn>49<\/mml:mn><\/mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>G allele was found among patients, and this variant was not found to correlate with RA. Assaying the possible genotype variations, the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>+<\/mml:mo><mml:msup><mml:mrow><mml:mn>49<\/mml:mn><\/mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>G-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>C<\/mml:mi><mml:mi>T<\/mml:mi><mml:msup><mml:mrow><mml:mn>60<\/mml:mn><\/mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>G allelic combination was accumulated in seropositive RA-subtypes, and was associated with the risk of RA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.73<\/mml:mn><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><\/mml:math>for the whole RA-population). Although the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>+<\/mml:mo><mml:msup><mml:mrow><mml:mn>49<\/mml:mn><\/mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>G allele did not mean a predisposition to RA alone, in combination with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>C<\/mml:mi><mml:mi>T<\/mml:mi><mml:msup><mml:mrow><mml:mn>60<\/mml:mn><\/mml:mrow><mml:mo>\u2217<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>G it, also conferred risk, suggesting that the<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>+<\/mml:mo><mml:mn>49<\/mml:mn><mml:mi>A<\/mml:mi><mml:mo>\/<\/mml:mo><mml:mi>G<\/mml:mi><\/mml:mrow><\/mml:math>variant is associated with the risk of RA only in certain haplotypes.<\/jats:p>","DOI":"10.4061\/2010\/285974","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T16:00:07Z","timestamp":1251388807000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Cytotoxic T lymphocyte-Associated Antigen +49G Variant Confers Risk for Anti-CCP- and Rheumatoid Factor-Positive Type of Rheumatoid Arthritis Only in Combination with CT60<sup>\u2217<\/sup>G Allele"],"prefix":"10.4061","volume":"2010","author":[{"given":"Bernadett","family":"Farago","sequence":"first","affiliation":[{"name":"Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kisfali","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Magyari","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Polgar","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Melegh","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Child Development, University of Pecs, Pecs 7624, 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