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The basic assumptions were identified, their consequences on predicted cell survival were analyzed, and the advantages and drawbacks of each approach were outlined. In addition to \u201chistorical\u201d approaches such as the Target Theory, the Linear\u2010Quadratic model, the Theory of Dual Radiation Action and Katz\u2032 model, the more recent Local Effect Model was discussed, focusing on its application in Carbon\u2010ion hadrontherapy. Furthermore, a mechanistic model developed at the University of Pavia and based on the relationship between cell inactivation and chromosome aberrations was presented, together with recent results; the good agreement between model predictions and literature experimental data on different radiation types (photons, protons, alpha particles, and Carbon ions) supported the idea that asymmetric chromosome aberrations like dicentrics and rings play a fundamental role for cell death. Basing on these results, a reinterpretation of the TDRA was also proposed, identifying the TDRA \u201csublesions\u201d and \u201clesions\u201d as clustered DNA double\u2010strand breaks and (lethal) chromosome aberrations, respectively.<\/jats:p>","DOI":"10.4061\/2010\/350608","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T17:31:03Z","timestamp":1286299863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["From DNA Radiation Damage to Cell Death: Theoretical Approaches"],"prefix":"10.1155","volume":"2010","author":[{"given":"Francesca","family":"Ballarini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,5]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Radiation Biophysics","author":"Alpen E. 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