{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:16:15Z","timestamp":1760645775203},"reference-count":26,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Nonunion fractures and aseptic bone necrosis are two pathological conditions having some impairment of the cellular part of the repair: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direct injection\u201415 to 150\u2009ml\u2014was made in 4 case series studies. In another, the bone marrow aspirate was concentrated before injection. The results were good. In bone necrosis, only one level 1 study was published. The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse. In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%. These results are interesting but need confirmation by controlled studies.<\/jats:p>","DOI":"10.4061\/2010\/410170","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T17:32:35Z","timestamp":1288114355000},"page":"1-4","source":"Crossref","is-referenced-by-count":13,"title":["Phases 1\u20133 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures"],"prefix":"10.1155","volume":"2010","author":[{"given":"Jean-Philippe","family":"Hauzeur","sequence":"first","affiliation":[{"name":"Department of Rheumatology, CHU Sart Tilman, B35, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Gangji","sequence":"additional","affiliation":[{"name":"Rheumatology and Rehabilitation Medicine Department, Erasme Hospital, Free University of Brussels, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B12.19671"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2008.10.009"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9112-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2008.06.005"},{"issue":"37","key":"12","first-page":"2629","volume":"89","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"1","key":"3","first-page":"33","volume":"83","year":"1997","journal-title":"Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9020-6"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1302\/0301-620X.83B3.10793","volume":"83","year":"2001","journal-title":"Journal of Bone and Joint Surgery B"},{"issue":"2","key":"6","first-page":"348","volume":"30","year":"2003","journal-title":"Journal of Rheumatology"},{"issue":"7","key":"7","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2106\/00004623-199707000-00011","volume":"79","year":"1997","journal-title":"Journal of Bone and Joint Surgery A"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B2.8818"},{"issue":"5","key":"9","first-page":"870","volume":"14","year":"1987","journal-title":"Journal of Rheumatology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.01521"},{"issue":"4","key":"14","first-page":"105","volume":"71","year":"1986","journal-title":"The Nebraska Medical Journal"},{"issue":"355, supplement","key":"15","first-page":"S257","year":"1998","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"256","key":"16","first-page":"280","year":"1990","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"4","key":"17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00005131-198912000-00002","volume":"3","year":"1989","journal-title":"Journal of orthopaedic trauma"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2106\/00004623-195638020-00003","volume":"38","year":"1956","journal-title":"The Journal of Bone and Joint Surgery A"},{"issue":"6","key":"19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3109\/17453679308994595","volume":"64","year":"1993","journal-title":"Acta Orthopaedica Scandinavica"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2004.01.009"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02215"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-10-20"},{"issue":"405","key":"23","first-page":"14","year":"2002","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"6","key":"24","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2106\/00004623-200406000-00006","volume":"86","year":"2004","journal-title":"Journal of Bone and Joint Surgery A"},{"issue":"10","key":"25","first-page":"776","volume":"21","year":"2008","journal-title":"Zhongguo Gu Shang"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-009-0939-0"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2010\/410170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2010\/410170.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2010\/410170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T15:30:18Z","timestamp":1497886218000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/sci\/2010\/410170\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":26,"alternative-id":["410170","410170"],"URL":"https:\/\/doi.org\/10.4061\/2010\/410170","relation":{},"ISSN":["1687-9678"],"issn-type":[{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}