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We here report that 5-AED limits inflammation and proinflammatory cytokines including TNF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b1<\/mml:mi><\/mml:math>in murine models of carrageenan-induced pleurisy and lippopolysaccaride- (LPS) induced septic shock. 5-AED binds to and transactivates sex steroid receptors with the same general rank order of potency (ER\u03b2 &gt; ER\u03b1 \u226b AR). 5-AED provides benefit in EAE in a dose-dependent fashion, even when treatment is delayed until onset of disease. The minimally effective dose may be as low as 4\u2009mg\/kg in mice. However, benefit was not observed when 5-AED was given in soluble formulation, leading to a short half-life and rapid clearance. These observations suggest that treatment with 5-AED limits the production of pro-inflammatory cytokines in these animal models and, ultimately, when formulated and administered properly, may be beneficial for patients with multiple sclerosis and other Th1-driven autoimmune diseases.<\/jats:p>","DOI":"10.4061\/2010\/757432","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T14:32:43Z","timestamp":1274193163000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice"],"prefix":"10.4061","volume":"2010","author":[{"given":"Ferdinando","family":"Nicoletti","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, University of Catania, Via Androne 83, 95124 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick L.","family":"Auci","sequence":"additional","affiliation":[{"name":"Harbor Biosciences, 4435 Eastgate Mall, Suite 400, San Diego, CA 92121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Mangano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, University of Catania, Via Androne 83, 95124 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Flores-Riveros","sequence":"additional","affiliation":[{"name":"Harbor Biosciences, 4435 Eastgate Mall, Suite 400, San Diego, CA 92121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Villegas","sequence":"additional","affiliation":[{"name":"Harbor Biosciences, 4435 Eastgate Mall, Suite 400, San Diego, CA 92121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Frincke","sequence":"additional","affiliation":[{"name":"Harbor Biosciences, 4435 Eastgate Mall, Suite 400, San Diego, CA 92121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Reading","sequence":"additional","affiliation":[{"name":"Harbor Biosciences, 4435 Eastgate Mall, Suite 400, San Diego, CA 92121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halina","family":"Offner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oregon Health and Science University, 3710 SW Veterans Hospital Road, Portland, OR 97201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"4\u20136","key":"1","first-page":"649","volume":"40","year":"1991","journal-title":"Journal of Steroid Biochemistry and Molecular 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