{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:40:50Z","timestamp":1777992050647,"version":"3.51.4"},"reference-count":33,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The relationship between C-reactive protein (CRP) elevation and ventricular tachycardia (VT) in arrhythmogenic right ventricular dysplasia\/cardiomyopathy (ARVD\/C) is unclear.<jats:italic>Methods and Results<\/jats:italic>. In 91 consecutive patients with either ARVD\/C with or without VT (cases) or idiopathic right ventricular outflow tract (RVOT) tachycardia (controls), blood sampling were taken to determine CRP levels. In ARVD\/C patients with VT, we analyzed the association between VT occurrences and CRP level. Sixty patients had ARVD\/C, and 31 had idiopathic RVOT VT. Patients with ARVD\/C had a significant higher level of CRP compared to those with RVOT VT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>3.5<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.9<\/mml:mn><\/mml:mrow><\/mml:math>versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>1.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.2<\/mml:mn><\/mml:mrow><\/mml:math>\u2009mg\/l,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.0004<\/mml:mn><\/mml:mrow><\/mml:math>). In ARVD\/C group, 77%, (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>46<\/mml:mn><\/mml:mrow><\/mml:math>) patients experienced VT. Of these, 37% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>17<\/mml:mn><\/mml:mrow><\/mml:math>) underwent blood testing for CRP within 24\u2009h after the onset of VT and the remaining 63% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>29<\/mml:mn><\/mml:mrow><\/mml:math>) after 24\u2009h of VT reduction. CRP level was similar in ARVD\/C patients with or without documented VT (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>3.6<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>5.1<\/mml:mn><\/mml:mrow><\/mml:math>\u2009mg\/l versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>3.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.1<\/mml:mn><\/mml:mrow><\/mml:math>\u2009mg\/l,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.372<\/mml:mn><\/mml:mrow><\/mml:math>). However, in patients with ARVD\/C and documented VT, CRP was significantly higher when measured within 24 hours following VT in comparison to that level when measured after 24\u2009h (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>4.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>6.2<\/mml:mn><\/mml:mrow><\/mml:math>\u2009mg\/l versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>3.0<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.4<\/mml:mn><\/mml:mrow><\/mml:math>\u2009mg\/l,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.049<\/mml:mn><\/mml:mrow><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. Inflammatory state is an active process in patients with ARVD\/C. Moreover, there is a higher level of CRP in patients soon after ventricular tachycardia, and this probably tends to decrease after the event.<\/jats:p>","DOI":"10.4061\/2010\/919783","type":"journal-article","created":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T11:45:11Z","timestamp":1282650311000},"page":"1-7","source":"Crossref","is-referenced-by-count":27,"title":["C-Reactive Protein in Arrhythmogenic Right Ventricular Dysplasia\/Cardiomyopathy and Relationship with Ventricular Tachycardia"],"prefix":"10.1155","volume":"2010","author":[{"given":"Aim\u00e9","family":"Bonny","sequence":"first","affiliation":[{"name":"Service de Cardiologie, H\u00f4pital Saint Camille, 2 rue des p\u00e8res camilliens, 94366 Bry-sur-Marne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Lellouche","sequence":"additional","affiliation":[{"name":"H\u00f4pital Henri-Mondor, F\u00e9d\u00e9ration de Cardiologie, 51, av Mal de Lattre de Tassigny, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Ditah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wayne State University, 5475 Woodward Avenue, Detroit, MI 48202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Hidden-Lucet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Rythmologie, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, 47-83, Boulevard de l\u2019H\u00f4pital, 75651 Paris, Cedex 13, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martial T.","family":"Yitemben","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine, Centre Hospitalier Le Cateau, 28, Boulevard Paturle, 59360 Le Cateau- Cambresis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Granger","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biostatistique, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, 47-83, Boulevard de l\u2019H\u00f4pital, 75651 Paris, Cedex 13, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Larrazet","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, H\u00f4pital Saint Camille, 2 rue des p\u00e8res camilliens, 94366 Bry-sur-Marne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Frank","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Rythmologie, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, 47-83, Boulevard de l\u2019H\u00f4pital, 75651 Paris, Cedex 13, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Rythmologie, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, 47-83, Boulevard de l\u2019H\u00f4pital, 75651 Paris, Cedex 13, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","first-page":"963","volume":"71","year":"1978","journal-title":"Arch Mal C\u0153ur Vaiss"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.65.2.384","volume":"65","year":"1982","journal-title":"Circulation"},{"issue":"3","key":"3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJM198801213180301","volume":"318","year":"1988","journal-title":"The New England Journal of Medicine"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.056"},{"issue":"11","key":"5","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1161\/01.CIR.101.11.e101","volume":"101","year":"2000","journal-title":"Circulation"},{"key":"6","first-page":"345","year":"2005","journal-title":"Cardiac Arrhythmias"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl473"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040967"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020190.45892.75"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807646"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/00365510802676848"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20430"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.06.003"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.05.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00470-9"},{"issue":"8","key":"17","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.CIR.103.8.1044","volume":"103","year":"2001","journal-title":"Circulation"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000077913.60364.D2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.05.001"},{"issue":"7","key":"20","first-page":"1459","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.10.017"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00787-7"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00498-4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.053"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20110"},{"issue":"5","key":"26","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/heart.83.5.588","volume":"83","year":"2000","journal-title":"Heart"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0800028"},{"issue":"5","key":"28","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/eurheartj\/14.5.717","volume":"14","year":"1993","journal-title":"European Heart Journal"},{"key":"29","first-page":"22","volume":"12","year":"1991","journal-title":"European Heart Journal"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.584532"},{"issue":"2","key":"31","first-page":"479","volume":"152","year":"1998","journal-title":"American Journal of Pathology"},{"issue":"5","key":"32","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.CIR.94.5.983","volume":"94","year":"1996","journal-title":"Circulation"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.052208.130419"}],"container-title":["Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2010\/919783.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2010\/919783.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crp\/2010\/919783.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T09:03:40Z","timestamp":1497863020000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crp\/2010\/919783\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":33,"alternative-id":["919783","919783"],"URL":"https:\/\/doi.org\/10.4061\/2010\/919783","relation":{},"ISSN":["2090-0597"],"issn-type":[{"value":"2090-0597","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}