{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:23:31Z","timestamp":1697037811862},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Osteoporosis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To find out the presence of osteoporosis in hemophilic arthropathy patients and its correlation with clinical severity and serum levels of magnesium, copper, and zinc.<jats:italic>Methods<\/jats:italic>. Joint score, functional assessment score, bone densitometry, and serum magnesium, copper and zinc were done in twenty male hemophilic arthropathy patients and twenty controls.<jats:italic>Results<\/jats:italic>. There was highly significant lower Z scores of lumbar spine and neck of femur in patients versus controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:mrow><\/mml:math>). Z score of neck of femur correlated negatively with total joint score (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.013<\/mml:mn><\/mml:mrow><\/mml:math>) and functional assessment score (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:mrow><\/mml:math>). Serum levels of copper and zinc correlated positively with Z score of neck of femur (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>, resp.).<jats:italic>Conclusion<\/jats:italic>. Osteoporosis represents a frequent concomitant observation in hemophiliacs. Screening of young hemophiliacs for osteoporosis is recommended with measuring serum levels of magnesium, copper, and zinc for better management of the disease.<\/jats:p>","DOI":"10.4061\/2011\/106380","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T19:01:46Z","timestamp":1317841306000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Osteoporosis in Hemophilic Arthropathy Patients: Correlation with Disease Severity and Serum Trace Minerals"],"prefix":"10.4061","volume":"2011","author":[{"given":"Eiman","family":"Mahmoud Ghaniema","sequence":"first","affiliation":[{"name":"Rheumatology and Rehabilitation Department, Ain Shams University, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Fathi Ahmed","sequence":"additional","affiliation":[{"name":"Rheumatology and Rehabilitation Department, Ain Shams University, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Raouf Amin","sequence":"additional","affiliation":[{"name":"Rheumatology and Rehabilitation Department, Ain Shams University, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryse","family":"Soliman Ayoub","sequence":"additional","affiliation":[{"name":"Internal Medicine Department (Hematology Unit), Ain Shams University, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0115-6"},{"key":"2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-2516.9.s1.9.x","volume":"9","year":"2003","journal-title":"Hemophilia"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF02722035","volume":"68","year":"2001","journal-title":"Indian Journal of 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