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A<jats:italic>\u03b2<\/jats:italic> is derived from amyloidogenic cleavage of amyloid precursor protein (A<jats:italic>\u03b2<\/jats:italic>PP) by <jats:italic>\u03b2<\/jats:italic>\u2010 and <jats:italic>\u03b3<\/jats:italic>\u2010secretase. In the nonamyloidogenic pathway, A<jats:italic>\u03b2<\/jats:italic>PP is cleaved by <jats:italic>\u03b1<\/jats:italic>\u2010secretases. These two pathways compete with each other, and enhancing the non\u2010amyloidogenic pathway has been suggested as a potential pharmacological approach for the treatment of AD. Since A<jats:italic>\u03b2<\/jats:italic>PP, <jats:italic>\u03b1<\/jats:italic>\u2010, <jats:italic>\u03b2<\/jats:italic>\u2010, and <jats:italic>\u03b3<\/jats:italic>\u2010secretases are membrane\u2010associated proteins, A<jats:italic>\u03b2<\/jats:italic>PP processing and A<jats:italic>\u03b2<\/jats:italic> production can be affected by the membrane composition and properties. There is evidence that membrane composition and properties, in turn, play a critical role in A<jats:italic>\u03b2<\/jats:italic> cytotoxicity associated with its conformational changes and aggregation into oligomers and fibrils. Understanding the mechanisms leading to changes in a membrane\u2032s biophysical properties and how they affect A<jats:italic>\u03b2<\/jats:italic>PP processing and A<jats:italic>\u03b2<\/jats:italic> toxicity should prove to provide new therapeutic strategies for prevention and treatment of AD.<\/jats:p>","DOI":"10.4061\/2011\/134971","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T17:39:02Z","timestamp":1300383542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impacts of Membrane Biophysics in Alzheimer\u2032s Disease: From Amyloid Precursor Protein Processing to A<i>\u03b2<\/i> Peptide\u2010Induced Membrane Changes"],"prefix":"10.1155","volume":"2011","author":[{"given":"Sholpan","family":"Askarova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.-M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0002-9440(10)65416-8","article-title":"Microglia in Alzheimer\u2032s disease and transgenic models: how close the fit?","volume":"154","author":"Dickson D. 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