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Lack of vaccines and emergence of drug resistance warrants the need for improved drug therapy and newer therapeutic intervention strategies against leishmaniasis. In the present study, we have investigated the effect of the natural indoloquinoline alkaloid cryptolepine on<jats:italic>L. donovani<\/jats:italic>AG83 promastigotes. Our results show that cryptolepine induces cellular dysfunction in<jats:italic>L. donovani<\/jats:italic>promastigotes, which leads to the death of this unicellular parasite. Interestingly, our study suggest that cryptolepine-induced cell death of<jats:italic>L. donovani<\/jats:italic>is counteracted by initial autophagic features elicited by the cells. For the first time, we show that autophagy serves as a survival mechanism in response to cryptolepine treatment in<jats:italic>L. donovani<\/jats:italic>promastigotes and inhibition of autophagy causes an early increase in the amount of cell death. This study can be exploited for designing better drugs and better therapeutic strategies against leishmaniasis in future.<\/jats:p>","DOI":"10.4061\/2011\/187850","type":"journal-article","created":{"date-parts":[[2011,3,6]],"date-time":"2011-03-06T09:07:18Z","timestamp":1299402438000},"page":"1-12","source":"Crossref","is-referenced-by-count":26,"title":["Cryptolepine-Induced Cell Death of<i>Leishmania donovani<\/i>Promastigotes Is Augmented by Inhibition of Autophagy"],"prefix":"10.4061","volume":"2011","author":[{"given":"Souvik","family":"Sengupta","sequence":"first","affiliation":[{"name":"Molecular Parasitology Laboratory, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayan","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Laboratory, Indian Institute of Chemical Biology, 4, Raja S. C. 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