{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:59:29Z","timestamp":1792807169813,"version":"4.5.0"},"reference-count":176,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T00:00:00Z","timestamp":1299542400000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Miyazaki Prefectural Industrial Support Foundation","id":[{"id":"https:\/\/ror.org\/00fb64e91","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Alzheimer's Disease"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>\n                    Whilst being environmentally abundant, aluminum is not essential for life. On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans. The relationship between aluminum exposure and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii Peninsula and Guam, and Alzheimer\u2032s disease (AD) has been suggested. In particular, the link between aluminum and Alzheimer\u2032s disease has been the subject of scientific debate for several decades. However, the complex characteristics of aluminum bioavailability make it difficult to evaluate its toxicity and therefore, the relationship remains to be established. Mounting evidence has suggested that significance of oligomerization of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010amyloid protein and neurotoxicity in the molecular mechanism of AD pathogenesis. Aluminum may play crucial roles as a cross\u2010linker in\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010amyloid oligomerization. Here, we review the detailed characteristics of aluminum neurotoxicity based on our own studies and the recent literatures. Our aim is to revisit the link between aluminum and AD and to integrate aluminum and amyloid cascade hypotheses in the context of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010amyloid oligomerization and the interactions with other metals.\n                  <\/jats:p>","DOI":"10.4061\/2011\/276393","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T13:46:48Z","timestamp":1299592008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":319,"title":["Link between Aluminum and the Pathogenesis of Alzheimer\u2032s Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses"],"prefix":"10.1155","volume":"2011","author":[{"given":"Masahiro","family":"Kawahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Kato-Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,8]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"273","article-title":"Amyotrophic lateral sclerosis and Parkinsonism-dementia in the Kii peninsula: comparison with the same disorders in Guam and with Alzheimer\u2032s disease","volume":"15","author":"Shiraki H.","year":"1991","journal-title":"Handbook of Clinical Neurology"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:9:1:83"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/ndt\/17.suppl_2.17","article-title":"The potential role of aluminium in Alzheimer\u2032s disease","volume":"17","author":"Campbell A.","year":"2002","journal-title":"Nephrology Dialysis Transplantation"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/env.3170060303","article-title":"Aluminium and the risk for Alzheimer\u2032s disease","volume":"6","author":"McLachlan D. 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