{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:01:23Z","timestamp":1791907283074,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":151,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Jose Lamas Foundation"},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltonen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Alzheimer's Disease"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is still challenging. Alzheimer\u2032s disease (AD), along with vascular dementia, the most important differential diagnosis for iNPH, has several potential cerebrospinal fluid (CSF) biomarkers which might help in the selection of patients for shunt treatment. The aim of this study was to compare a battery of CSF biomarkers including well\u2010known AD\u2010related proteins with CSF from patients with suspected iNPH collected from the external lumbar drainage test (ELD). A total of 35 patients with suspected iNPH patients were evaluated with ELD. CSF was collected in the beginning of the test, and the concentrations of total tau, ptau<jats:sub>181<\/jats:sub>, A<jats:italic>\u03b2<\/jats:italic><jats:sub>42<\/jats:sub>, NFL, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, TGF<jats:italic>\u03b2<\/jats:italic>1, and VEGF were analysed by ELISA. Twenty\u2010six patients had a positive ELD result\u2014that is, their gait symptoms improved; 9\u2009patients had negative ELD. The levels of all analyzed CSF biomarkers were similar between the groups and none of them predicted the ELD result in these patients. Contrary to expectations lumbar CSF TNF\u2010<jats:italic>\u03b1<\/jats:italic> concentration was low in iNPH patients.<\/jats:p>","DOI":"10.4061\/2011\/312526","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T17:34:49Z","timestamp":1306949689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1155","volume":"2011","author":[{"given":"Ville","family":"Leinonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lata G.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona S.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Dello Iacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Grevet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000168187.01077.2F"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000168186.45363.4D"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000168187.01077.2F"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ana.22100","article-title":"Amyloid and tau proteins in cortical brain biopsy and Alzheimer\u2032s disease","volume":"68","author":"Leinonen V.","year":"2010","journal-title":"Annals of Neurology"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000168184.01002.60"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3171\/2010.8.JNS10157","article-title":"Comparison between 3\u2009infusion methods to measure cerebrospinal fluid outflow conductance","volume":"113","author":"Sundstr\u00f6m N.","year":"2010","journal-title":"Journal of Neurosurgery"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000363408.69856.B8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20108454\u20103\u201011"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2217\/bmm.09.37","article-title":"Ongoing search for diagnostic biomarkers in idiopathic normal pressure hydrocephalus","volume":"3","author":"Tarnaris A.","year":"2009","journal-title":"Biomarkers in Medicine"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2008.05422.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20104580(02)00187\u20102"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.06.001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/jnnp.2008.155671","article-title":"High CSF transforming growth factor beta levels after subarachnoid haemorrhage: association with chronic communicating hydrocephalus","volume":"80","author":"Douglas M. 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