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In this study, we predicted CK binding proteins via the use of bioinformatic tools such as protein-protein interaction (PPI) mappings and suggest the putative hub proteins for CK interactions. We obtained 123 proteins for brain type CK and 85 proteins for muscle type CK in the interaction networks. Among them, several hub proteins such as NFKB1, FHL2, MYOC, and ASB9 were predicted. Determination of the binding factors of CK can further promote our understanding of the roles of CK in physiological conditions.<\/jats:p>","DOI":"10.4061\/2011\/328249","type":"journal-article","created":{"date-parts":[[2011,8,25]],"date-time":"2011-08-25T12:16:34Z","timestamp":1314274594000},"page":"1-12","source":"Crossref","is-referenced-by-count":3,"title":["Computational Simulations to Predict Creatine Kinase-Associated Factors: Protein-Protein Interaction Studies of Brain and Muscle Types of Creatine Kinases"],"prefix":"10.4061","volume":"2011","author":[{"given":"Wei-Jiang","family":"Hu","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Mei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Biology and Chemical Engineering, Jiaxing University, Jiaxing 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