{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:59:58Z","timestamp":1783655998814,"version":"3.55.0"},"reference-count":18,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Preventive Medicine"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To assess the immunogenicity of intradermal (ID) booster doses of Purified Chick Embryo Cell rabies vaccine (PCECV, Rabipur) administered to Thai schoolchildren one, three and five years after a primary ID pre-exposure (PrEP) vaccination series.<jats:italic>Methods<\/jats:italic>. In this follow-up study of a randomized, open-label, phase II clinical trial, two simulated post-exposure booster doses of PCECV were administered on days 0 and 3 intradermally to 703 healthy schoolchildren, one, three or five years after primary vaccination with either two or three ID doses of 0.1\u2009mL PCECV. Blood was drawn immediately before and 7, 14 and 365 days after the first booster dose to determine rabies virus neutralizing antibody (RVNA) concentrations.<jats:italic>Results<\/jats:italic>. An anamnestic response of approximately 30-fold increase in RVNA concentrations was demonstrated within 14 days after booster. All children (100%) developed adequate RVNA concentrations above 0.5\u2009IU\/mL. No vaccine related serious adverse events were seen in any of the vaccinees.<jats:italic>Conclusion<\/jats:italic>. ID rabies PrEP with PCECV is safe and immunogenic in schoolchildren and the anamnestic response to a two booster dose vaccination series was found to be adequate one, three, and five years after a two- or three-dose primary PrEP vaccination series.<\/jats:p>","DOI":"10.4061\/2011\/403201","type":"journal-article","created":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T07:59:26Z","timestamp":1312790366000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren"],"prefix":"10.4061","volume":"2011","author":[{"given":"Thavatchai","family":"Kamoltham","sequence":"first","affiliation":[{"name":"Office of Permanent Secretary, Ministry of Health, Nonthaburi 11120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiravan","family":"Thinyounyong","sequence":"additional","affiliation":[{"name":"Provincial Health Office of Phetchabun, Ministry of Health, Phetchabun 67160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakamatz","family":"Khawplod","sequence":"additional","affiliation":[{"name":"Queen Saovabha Memorial Institute, Thai Red Cross Society and Department of Medicine, Chulalongkorn Hospital, 1871 Rama 4 Road, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phran","family":"Phraisuwan","sequence":"additional","affiliation":[{"name":"Provincial Health Office of Phetchabun, Ministry of Health, Phetchabun 67160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phana","family":"Phongchamnaphai","sequence":"additional","affiliation":[{"name":"Provincial Health Office of Phetchabun, Ministry of Health, Phetchabun 67160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlind","family":"Anders","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics GmbH, Medical Affairs, Emil-von-Behring-Str. 76, Marburg 35041, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudius","family":"Malerczyk","sequence":"additional","affiliation":[{"name":"Novartis Vaccines and Diagnostics GmbH, Medical Affairs, Emil-von-Behring-Str. 76, Marburg 35041, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"5","key":"1","first-page":"375","volume":"81","year":"2003","journal-title":"Bulletin of the World Health Organization"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.09.027"},{"issue":"5","key":"3","first-page":"360","volume":"83","year":"2005","journal-title":"Bulletin of the World Health Organization"},{"issue":"5","key":"5","first-page":"615","volume":"71","year":"1993","journal-title":"Bulletin of the World Health Organization"},{"issue":"1","key":"6","first-page":"41","volume":"7","year":"1989","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"issue":"41","key":"7","first-page":"319","volume":"76","year":"2001","journal-title":"Weekly Epidemiological Record"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1086\/375605"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/clinids\/13.4.644","volume":"13","year":"1991","journal-title":"Reviews of Infectious Diseases"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.02.036"},{"issue":"5","key":"11","first-page":"693","volume":"78","year":"2000","journal-title":"Bulletin of the World Health Organization"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(02)90113-X"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.02.044"},{"issue":"5","key":"14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4161\/hv.4.5.5987","volume":"4","year":"2008","journal-title":"Human Vaccines"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181906351"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90309-7"},{"issue":"23","key":"17","first-page":"354","year":"1973","journal-title":"Monograph Series. 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