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Prepubertal children in particular have a higher prevalence of isolated ocular symptoms, lower frequency of acetylcholine receptor antibodies, and a higher probability of achieving remission. Diagnosis in young children can be complicated by the need to differentiate from congenital myasthenic syndromes, which do not have an autoimmune basis. Treatment commonly includes anticholinesterases, corticosteroids with or without steroid-sparing agents, and newer immune modulating agents. Plasma exchange and intravenous immunoglobulin (IVIG) are effective in preparation for surgery and in treatment of myasthenic crisis. Thymectomy increases remission rates. Diagnosis and management of children with JMG should take account of their developmental needs, natural history of the condition, and side-effect profiles of treatment options.<\/jats:p>","DOI":"10.4061\/2011\/404101","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T15:01:11Z","timestamp":1320159671000},"page":"1-7","source":"Crossref","is-referenced-by-count":26,"title":["Juvenile Myasthenia Gravis: A Paediatric Perspective"],"prefix":"10.4061","volume":"2011","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-1684","authenticated-orcid":true,"given":"Maria F.","family":"Finnis","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology, Children's Hospital, John Radcliffe Hospital, Oxford OX3 9DU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Jayawant","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology, Children's Hospital, John Radcliffe Hospital, 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