{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:57:27Z","timestamp":1784735847421,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. We pooled data from four studies, to establish whether exercise training programs were able to modulate systemic cytokine levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). A second aim was to establish if differences in ExT regimens are related to degree of change in cytokines and peak VO<jats:sub>2<\/jats:sub>.<jats:italic>Methods<\/jats:italic>. Data from four centres relating to training protocol, exercise capacity, and cytokine measures (TNF-alpha and IL-6) were pooled for analysis.<jats:italic>Results<\/jats:italic>. Data for 106 CHF patients were collated (98 men, age 62\u2009\u00b1\u200910\u2009yrs, wt 79\u2009\u00b1\u200914\u2009Kg). Patients were moderately impaired (peak VO<jats:sub>2<\/jats:sub>16.9\u2009\u00b1\u20094.4\u2009mls\/kg\/min), with moderate LV systolic dysfunction (EF 30\u2009\u00b1\u20096.9%), 78% (83) had ischaemic cardiomyopathy. After ExT, peak VO<jats:sub>2<\/jats:sub>increased 1.4\u2009\u00b1\u20093.4\u2009ml\/kg\/min (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:math>), serum TNF-alpha decreased 1.9\u2009\u00b1\u20098.6\u2009pg\/ml (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.02<\/mml:mn><\/mml:math>) and IL-6 was not significantly changed (0.5 \u00b1 5.4\u2009pg\/ml,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.32<\/mml:mn><\/mml:math>) for the whole group. Baseline and post-training peak VO<jats:sub>2<\/jats:sub>changes were not correlated with change in cytokine levels.<jats:italic>Conclusions<\/jats:italic>. Exercise training reduces levels TNF-alpha but not IL-6 in CHF. However, across a heterogenic patient group, change in peak VO<jats:sub>2<\/jats:sub>was not correlated with alterations in cytokine levels. While greater exercise volume (hours) was superior in improving peak VO<jats:sub>2<\/jats:sub>, no particular characteristic of ExT regimes appeared superior in effecting change in serum cytokines.<\/jats:p>","DOI":"10.4061\/2011\/532620","type":"journal-article","created":{"date-parts":[[2011,2,28]],"date-time":"2011-02-28T01:34:02Z","timestamp":1298856842000},"page":"1-6","source":"Crossref","is-referenced-by-count":39,"title":["Effect of Exercise Training on Interleukin-6, Tumour Necrosis Factor Alpha and Functional Capacity in Heart Failure"],"prefix":"10.1155","volume":"2011","author":[{"given":"Neil A.","family":"Smart","sequence":"first","affiliation":[{"name":"Faculty of Health Science, Bond University, QLD 4229, Australia"},{"name":"Department of Exericse Physiology, University of New England, Armidale NSW 2351, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alf I.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of 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