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This inhibitor was administrated before the injection of pemphigus IgG into neonatal mice. The main results of the present investigation are as follows: (1) pemphigus IgG induces intraepidermal blisters in Balb\/c neonatal mice; (2) keratinocytes around the blister and acantholytic cells undergo apoptosis; (3) the caspases inhibitor Ac-DEVD-CMK prevents apoptosis; (4) the inhibition of the caspase pathway prevents blister formation. In conclusion, inhibition of the caspase pathway may be a promising therapeutic tool that can help in the treatment of pemphigus flare ups.<\/jats:p>","DOI":"10.4061\/2011\/563091","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T12:32:46Z","timestamp":1299069166000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus"],"prefix":"10.4061","volume":"2011","author":[{"given":"Deyanira","family":"Pacheco-Tovar","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Centro de Biolog\u00eda Experimental, Universidad Aut\u00f3noma de Zacatecas, Chepinque 306, Col. 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