{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:35:27Z","timestamp":1791650127035,"version":"4.3.4"},"reference-count":85,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Grant Agency of Charles University","award":["GAUK 84208"],"award-info":[{"award-number":["GAUK 84208"]}]},{"name":"Grant Agency of Charles University","award":["000 237280"],"award-info":[{"award-number":["000 237280"]}]},{"name":"Ministry of Health, Czech Republic","award":["GAUK 84208"],"award-info":[{"award-number":["GAUK 84208"]}]},{"name":"Ministry of Health, Czech Republic","award":["000 237280"],"award-info":[{"award-number":["000 237280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Osteoporosis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Bone disease in patients with juvenile idiopathic arthritis (JIA) is associated with focal (joint erosion and juxtaarticular osteopenia) and systemic bone loss (generalized osteopenia or reduction of bone mass density). Pathophysiology of bone loss is multifactorial and involves particularly proinflammatory cytokines and deleterious effects of glucocorticoid therapy. Clinical studies in patients with JIA indicate excessive activation of osteoclastogenesis and reduction of bone formation. Reduction of physical activity, muscle atrophy caused by high disease activity, and compulsory restriction in movements are also associated with bone loss. In patients with JIA, the disease can be complicated by growth cartilage involvement and systemic or local growth retardation. In the absence of preventive measures, fragility fractures can occur even at an early age.<\/jats:p>","DOI":"10.4061\/2011\/569417","type":"journal-article","created":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T17:31:51Z","timestamp":1298223111000},"page":"1-7","source":"Crossref","is-referenced-by-count":25,"title":["Secondary Osteoporosis in Patients with Juvenile Idiopathic Arthritis"],"prefix":"10.4061","volume":"2011","author":[{"given":"Kristyna","family":"Brabnikova Maresova","sequence":"first","affiliation":[{"name":"Institute of Rheumatology, Slupi 4, 128 50, Prague 2, Czech Republic"},{"name":"Department of Rheumatology, First Faculty of Medicine, Charles University in Prague, Kate\u0159insk\u00e1 32, 121 08 Prague 2, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"5","key":"1","first-page":"499","volume":"24","year":"2006","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"6","key":"2","first-page":"1296","volume":"29","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200098"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390506"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/1529-0131(200003)43:3<531::AID-ANR8>3.0.CO;2-X","volume":"43","year":"2000","journal-title":"Arthritis & Rheumatism"},{"issue":"5","key":"6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0022-3476(06)80006-5","volume":"122","year":"1993","journal-title":"Journal of Pediatrics"},{"issue":"7","key":"7","first-page":"1189","volume":"20","year":"1993","journal-title":"Journal of Rheumatology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401108"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/art.11097"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<790::AID-ANR24>3.0.CO;2-G"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1504::AID-ANR13>3.0.CO;2-0"},{"issue":"5","key":"12","first-page":"1065","volume":"29","year":"2002","journal-title":"Journal of Rheumatology"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02555248","volume":"41","year":"1987","journal-title":"Calcified Tissue International"},{"key":"14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/ard.19.2.135","volume":"19","year":"1960","journal-title":"Annals of the Rheumatic Diseases"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.048835"},{"issue":"5","key":"16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/adc.57.5.377","volume":"57","year":"1982","journal-title":"Archives of Disease in Childhood"},{"key":"17","first-page":"S119","volume":"43","year":"2000","journal-title":"Arthritis & Rheumatism"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/art.20128"},{"issue":"4","key":"19","first-page":"351","volume":"6","year":"2006","journal-title":"Journal of Musculoskeletal Neuronal Interactions"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh381"},{"issue":"4","key":"21","first-page":"826","volume":"29","year":"2002","journal-title":"Journal of Rheumatology"},{"issue":"58","key":"22","first-page":"34","volume":"27","year":"2000","journal-title":"Journal of Rheumatology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.1970"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.116297"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/art.22420"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei091"},{"issue":"7","key":"27","first-page":"1413","volume":"31","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83179-8"},{"issue":"1","key":"29","first-page":"54","volume":"10","year":"2008","journal-title":"Ortopedia Traumatologia Rehabilitacja"},{"issue":"2","key":"30","first-page":"251","volume":"17","year":"1999","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"2, supplement","key":"31","first-page":"ii11","volume":"42","year":"2003","journal-title":"Rheumatology"},{"key":"32","first-page":"iii10","volume":"43","year":"2004","journal-title":"Rheumatology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/art.10097"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-007-9070-0"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523394"},{"issue":"3","key":"36","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4049\/jimmunol.138.3.775","volume":"138","year":"1987","journal-title":"Journal of Immunology"},{"key":"37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-4419-9072-3_22","volume":"544","year":"2003","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(03)00841-2"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.09.008"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2003.10.005"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4320"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/nri2094"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141557"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1186\/ar1478"},{"issue":"9","key":"45","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","volume":"103","year":"1999","journal-title":"Journal of Clinical Investigation"},{"issue":"5","key":"46","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.170.5.2655","volume":"170","year":"2003","journal-title":"Journal of Immunology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81569-X"},{"issue":"7","key":"48","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","volume":"95","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"49","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1210\/endo.139.10.6331","volume":"139","year":"1998","journal-title":"Endocrinology"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8586"},{"issue":"2","key":"51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","volume":"89","year":"1997","journal-title":"Cell"},{"issue":"1","key":"52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1359\/jbmr.2000.15.1.2","volume":"15","year":"2000","journal-title":"Journal of Bone and Mineral Research"},{"issue":"7","key":"53","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/art.10388","volume":"46","year":"2002","journal-title":"Arthritis & Rheumatism"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1002\/art.22433"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0701-3"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1080\/03009740802116224"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0805-3"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1002\/art.20963"},{"issue":"1","key":"60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF03347283","volume":"21","year":"1998","journal-title":"Journal of Endocrinological Investigation"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070121"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1038\/nm1538"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-006-9002-4"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28551"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.017"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1002\/art.21392"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2005.01.002"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039032"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei025"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-0043-0"},{"issue":"3","key":"71","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11914-005-0017-7","volume":"3","year":"2005","journal-title":"Current Osteoporosis Reports"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050189"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.199"},{"issue":"11","key":"74","first-page":"2395","volume":"28","year":"2001","journal-title":"Journal of Rheumatology"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.3.245"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh592"},{"issue":"12","key":"77","first-page":"2481","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"78"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82424-2"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900028"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-0008-3"},{"issue":"1, supplement","key":"82","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000053210","volume":"53","year":"2000","journal-title":"Hormone Research"},{"issue":"5","key":"83","first-page":"1287","volume":"27","year":"2000","journal-title":"Journal of Rheumatology"},{"issue":"4","key":"84","first-page":"1073","volume":"27","year":"2000","journal-title":"Journal of Rheumatology"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.12.5737"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"}],"container-title":["Journal of Osteoporosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jos\/2011\/569417.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jos\/2011\/569417.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jos\/2011\/569417.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T09:05:18Z","timestamp":1685955918000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jos\/2011\/569417\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":85,"alternative-id":["569417","569417"],"URL":"https:\/\/doi.org\/10.4061\/2011\/569417","relation":{},"ISSN":["2042-0064"],"issn-type":[{"value":"2042-0064","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}