{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T01:51:08Z","timestamp":1786499468432,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Bone Health Alliance"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Osteoporosis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>This study was conducted to assess the occurrence of fractures in solid-organ transplant recipients.<jats:italic>Methods<\/jats:italic>. Medical record review and surveys were performed. Patients received less than 6 months of glucocorticoids.<jats:italic>Results<\/jats:italic>. Of 351 transplant patients, 175 patients provided fracture information, with 48 (27.4%) having fractured since transplant (2\u20136 years). Transplants included 19 kidney\/liver (50% male), 47 kidney\/pancreas (53% male), 92 liver (65% male), and 17 pancreas transplants (41% male). Age at transplant was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>50.8<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>10.3<\/mml:mn><\/mml:mrow><\/mml:math>years. Fractures were equally seen across both genders and transplant types. Calcium supplementation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>94<\/mml:mn><\/mml:math>) and bisphosphonate therapy (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>52<\/mml:mn><\/mml:math>) were observed, and an association with a lower risk of fractures was noted for bisphosphonate users (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.45<\/mml:mn><\/mml:math>95% C.I. 0.24, 0.85). Fracture location included 8 (16.7%) foot, 12 (25.0%) vertebral, 3 (6.3%) hand, 2 (4.2%) humerus, 5 (10.4%) wrist, 10 (20.8%) fractures at other sites, and 7 (14.6%) multiple fractures. The estimated relative risk of fracture was nearly seventeen-times higher in male liver transplant recipients ages 45\u201364 years compared with the general male population, and comparable to fracture rates on conventional immunosuppressant regimens.<jats:italic>Conclusion<\/jats:italic>. We identify a high frequency of fractures in transplant recipients despite limited glucocorticoid use.<\/jats:p>","DOI":"10.4061\/2011\/591793","type":"journal-article","created":{"date-parts":[[2011,9,12]],"date-time":"2011-09-12T19:00:54Z","timestamp":1315854054000},"page":"1-8","source":"Crossref","is-referenced-by-count":29,"title":["Elevated Incidence of Fractures in Solid-Organ Transplant Recipients on Glucocorticoid-Sparing Immunosuppressive Regimens"],"prefix":"10.4061","volume":"2011","author":[{"given":"B. 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