{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:23:57Z","timestamp":1761675837497,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology Research International"],"published-print":{"date-parts":[[2011,3,30]]},"abstract":"<jats:p>We describe the clinical, gross and microscopic features of undifferentiated uterine stromal sarcoma associated with osteoclast-like giant cells. A case of low-grade endometrial stromal sarcoma is already described in association with osteoclast-like giant cells; however, the current case differs in that the tumor was a high grade and did not show any evidence of smooth muscle or epithelioid differentiation and was shown to be strongly positive for CD10 and focally for WT-1 and Inhibin supporting an endometrial stromal origin. The associated osteoclast-like giant cells were abundant, evenly distributed within the tumor and showed strong positivity for CD68. Interestingly, rare (less than 2%) giant cells also showed weak cytoplasmic positivity for b-hCG. The tumor infiltrated deep into the myometrium and had marked lymphovascular invasion. Although the regional lymph nodes and peritoneal washings were negative, the lesion showed a highly aggressive clinical course. Despite treatment, the tumor disseminated within the abdominal cavity and lungs and ultimately led to the patient's demise within 9 months of the diagnosis.<\/jats:p>","DOI":"10.4061\/2011\/629840","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T17:54:18Z","timestamp":1301507658000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Case Report of Undifferentiated Endometrial Sarcoma in Association with Osteoclast-Like Giant Cells"],"prefix":"10.1155","volume":"2011","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-4976","authenticated-orcid":true,"given":"Svetoslav","family":"Bardarov","sequence":"first","affiliation":[{"name":"Department of Pathology, 97 Amity Street, Brooklyn, NY 11201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim","family":"Khachaturov","sequence":"additional","affiliation":[{"name":"Department of Pathology, 97 Amity Street, Brooklyn, NY 11201, 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