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The choice of which RRT modality to use depends on numerous criteria that are both patient and treatment center specific. Surprisingly, despite decades of use, no randomized, controlled trial study involving RRT in pediatrics has been performed. Because of these factors, clear-cut consensus is lacking regarding key questions surrounding RRT delivery. In this paper, we will summarize existing data concerning RRT use in children. We discuss the major modalities and the data-driven specifics of each, followed by controversies in RRT. As no standard of care is in widespread use for RRT in AKI or in multiorgan disease, we conclude in this paper that prospective studies of RRT are needed to identify best practice guidelines.<\/jats:p>","DOI":"10.4061\/2011\/785392","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T17:34:35Z","timestamp":1306949675000},"page":"1-8","source":"Crossref","is-referenced-by-count":33,"title":["Acute Renal Replacement Therapy in Pediatrics"],"prefix":"10.4061","volume":"2011","author":[{"given":"Rajit K.","family":"Basu","sequence":"first","affiliation":[{"name":"Division of Critical Care and Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9902-2730","authenticated-orcid":true,"given":"Derek 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