{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:41:34Z","timestamp":1789591294698,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmune Diseases"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>\n                    Myasthenia gravis (MG) is characterized by reduced muscle endurance and is often accompanied by respiratory complications. Improvement of respiratory function is therefore an important objective in MG therapy. A previous study demonstrated that respiratory muscle endurance training (RMET) over four weeks increased respiratory muscle endurance of MG patients to about 200% of baseline. The purpose of the present study was to establish an appropriate maintenance training and to test its effects over four months. Ten patients with mild to moderate MG participated in this study. During the first month, they performed five training sessions per week. For the following 3 months, training frequency was reduced to five sessions per two weeks. Myasthenia score, lung function, and respiratory endurance were determined prior to training, after the first month, and after 4 months. Myasthenia score improved from\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mn>0.71<\/mml:mn>\n                        <mml:mo>\u00b1<\/mml:mo>\n                        <mml:mn>0.1<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    to\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mn>0.56<\/mml:mn>\n                        <mml:mo>\u00b1<\/mml:mo>\n                        <mml:mn>0.1<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>P<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.007<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ). Respiratory endurance time increased from\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mn>6.1<\/mml:mn>\n                        <mml:mo>\u00b1<\/mml:mo>\n                        <mml:mn>0.8<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    to\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mn>20.3<\/mml:mn>\n                        <mml:mo>\u00b1<\/mml:mo>\n                        <mml:mn>3.0<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    min (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>P<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.001<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ). In conclusion, this RMET maintenance program is feasible and is significantly beneficial for MG patients.\n                  <\/jats:p>","DOI":"10.4061\/2011\/808607","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T11:04:43Z","timestamp":1316516683000},"page":"1-7","source":"Crossref","is-referenced-by-count":19,"title":["Long-Term Respiratory Muscle Endurance Training in Patients with Myasthenia Gravis: First Results after Four Months of Training"],"prefix":"10.4061","volume":"2011","author":[{"given":"Beate","family":"Rassler","sequence":"first","affiliation":[{"name":"Carl Ludwig Institute of Physiology, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Marx","sequence":"additional","affiliation":[{"name":"Carl Ludwig Institute of Physiology, University of Leipzig, 04103 Leipzig, 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