{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:02:11Z","timestamp":1769220131860,"version":"3.49.0"},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Changes in peripheral muscle in heart failure lead to a shift from aerobic to early anaerobic metabolism during exercise leading to ergoreflex overactivation and exaggerated hyperventilation evaluated by the VE\/VCO<jats:sub>2<\/jats:sub>slope.<jats:italic>Methods<\/jats:italic>. 50 patients (38 males, years) performed cardio-pulmonary exercise test with gaz exchange measurement and echocardiographic evaluation before and 6 months after CRT.<jats:italic>Results<\/jats:italic>. The peak respiratory exchange (VCO<jats:sub>2<\/jats:sub>\/ VO<jats:sub>2<\/jats:sub>) ratio was significantly reduced from to () and the time to the anaerobic threshold was increased from to seconds (). Peak VO<jats:sub>2<\/jats:sub>, VE\/VCO<jats:sub>2<\/jats:sub>, peak circulatory power and NYHA were improved after CRT ( to ml\/kg\/min (), to (), to \u2009mmHg.ml\/kg\/min () and to ()). In addition, left ventricular ejection fraction and end-systolic volumes were improved from to % () and from to ml ().<jats:italic>Conclusion<\/jats:italic>. We suggest that CRT leads to an increase in oxidative muscular metabolism and postponed anaerobic threshold reducing exaggerated hyperventilation during exercise.<\/jats:p>","DOI":"10.4061\/2011\/830279","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T06:33:28Z","timestamp":1292913208000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Response to Cardiac Resynchronization Therapy: The Muscular Metabolic Pathway"],"prefix":"10.1155","volume":"2011","author":[{"given":"J\u00e9r\u00e9mie","family":"Jaussaud","sequence":"first","affiliation":[{"name":"Division de Cardiologie Clinique, H\u00f4pital Cardiologique, du Haut L\u00e9v\u00eaque, CHU de Bordeaux, Avenue Magellan, 33600 Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Blanc","sequence":"additional","affiliation":[{"name":"Division de Cardiologie Clinique, H\u00f4pital Cardiologique, du Haut L\u00e9v\u00eaque, CHU de 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