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Two combined conjugate vaccines were developed to help protect infants and young children in countries where the incidence of meningococcal serogroup C or serogroup C and Y disease is important: Hib-MenC-TT vaccine, which offers protection against<jats:italic>Haemophilus influenzae<\/jats:italic>type b and<jats:italic>Neisseria meningitidis<\/jats:italic>serogroup C diseases, is approved in several countries; and Hib-MenCY-TT vaccine, which adds<jats:italic>N. meningitidis<\/jats:italic>serogroup Y antigen, is currently in the final stages of development. Additionally, a tetravalent conjugate vaccine (MenACWY-TT) designed to help protect against four meningococcal serogroups is presently being evaluated for global use in all age groups. All of these vaccines were shown to be highly immunogenic and to have clinically acceptable safety profiles.<\/jats:p>","DOI":"10.4061\/2011\/846756","type":"journal-article","created":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T11:59:27Z","timestamp":1312804767000},"page":"1-17","source":"Crossref","is-referenced-by-count":22,"title":["Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience"],"prefix":"10.4061","volume":"2011","author":[{"given":"Jacqueline M.","family":"Miller","sequence":"first","affiliation":[{"name":"GlaxoSmithKline Biologicals, 2301 Renaissance Boulevard, King of Prussia, PA 19406, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcisa","family":"Mesaros","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Biologicals, Avenue Fleming 20 (W23), 1300 Wavre, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Van Der Wielen","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Biologicals, Avenue Fleming 20 (W23), 1300 Wavre, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaela","family":"Baine","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Biologicals, 2301 Renaissance Boulevard, King of Prussia, PA 19406, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2006.00051.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1586\/erv.10.3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.03.034"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1086\/504804"},{"issue":"5","key":"5","first-page":"342","volume":"80","year":"2002","journal-title":"Bulletin of the World Health Organization"},{"key":"6","year":"1998"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8305.2010.00448.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1086\/323403"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1590\/S0001-37652005000200009","volume":"77","year":"2005","journal-title":"Anais da Academia Brasileira de Ciencias"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1086\/649209"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1086\/340050"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1086\/315158"},{"issue":"4","key":"13","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0022-3476(81)80250-8","volume":"99","year":"1981","journal-title":"Journal of Pediatrics"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441807"},{"issue":"6","key":"15","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1001\/jama.286.6.694","volume":"286","year":"2001","journal-title":"Journal of the American Medical Association"},{"issue":"1","key":"16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/CMR.13.1.144-166.2000","volume":"13","year":"2000","journal-title":"Clinical Microbiology Reviews"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1086\/648963"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.11.018"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.063"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(99)90106-2"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01639.x"},{"issue":"6","key":"22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3201\/eid0906.020565","volume":"9","year":"2003","journal-title":"Emerging Infectious Diseases"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1086\/507339"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1086\/511646"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1086\/339010"},{"issue":"4","key":"26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4269\/ajtmh.2009.80.619","volume":"80","year":"2009","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1017\/S0950268898001848","volume":"122","year":"1999","journal-title":"Epidemiol Infect"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08416-7"},{"issue":"3","key":"31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2165\/00003495-199855030-00003","volume":"55","year":"1998","journal-title":"Drugs"},{"issue":"7","key":"32","first-page":"1","volume":"54","year":"2005","journal-title":"Morbidity and Mortality Weekly Report. 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