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The two lines were CD1d-restricted and expressed CD4<jats:sup>+<\/jats:sup>, DX5<jats:sup>+<\/jats:sup>, and the V\u03b14J\u03b1281 gene segment, of the T-cell receptor \u03b1 locus. Upon stimulation with \u03b1-galactosyl-ceramide (\u03b1-GalCer), both lines rapidly produced IL-2, IL-4, IFN-\u03b3, IL-10, and TNF-\u03b1. Strikingly, a similar cytokine response was also induced by thyroglobulin, one of the most abundant protein in the thyroid gland and a major autoantigen in human autoimmune thyroiditis. Transfer of the iNKT cell lines to syngeneic hosts enhanced autoimmune thyroiditis. Intraperitoneal injections of \u03b1-GalCer in iodine primed mice also induced thyroid disease. This paper reports for the first time that iNKT cells respond to thyroglobulin and enhance autoimmune thyroiditis in iodine fed NOD\u00b7H2<jats:sup>h4<\/jats:sup>mice.<\/jats:p>","DOI":"10.4061\/2011\/895923","type":"journal-article","created":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T17:33:57Z","timestamp":1302543237000},"page":"1-12","source":"Crossref","is-referenced-by-count":6,"title":["Invariant NKT Cell Lines Derived from the NOD\u00b7H2<sup>h4<\/sup>Mouse Enhance Autoimmune Thyroiditis"],"prefix":"10.4061","volume":"2011","author":[{"given":"Rajni B.","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Johns Hopkins University, Ross Research Building, 648, 720 Rutland Avenue, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoguang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Johns Hopkins University, Ross Research Building, 648, 720 Rutland Avenue, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Caturegli","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Johns Hopkins University, Ross Research Building, 648, 720 Rutland Avenue, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel R.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Johns Hopkins University, Ross Research Building, 648, 720 Rutland Avenue, Baltimore, MD 21205, USA"},{"name":"Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Johns Hopkins University, Ross Research Building, 648, 720 Rutland Avenue, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Lynne","family":"Burek","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Johns Hopkins University, Ross Research Building, 648, 720 Rutland Avenue, Baltimore, MD 21205, USA"},{"name":"Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Johns Hopkins University, Ross Research Building, 648, 720 Rutland Avenue, Baltimore, MD 21205, 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