{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:02:19Z","timestamp":1791518539724,"version":"4.3.4"},"reference-count":76,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Project Glomerulonephritis"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Hypercalcemia (HC) has been variably reported in kidney transplanted (KTx) recipients (5\u201315%). Calcium levels peak around the 3rd month after KTx and thereafter slightly reduce and stabilize. Though many factors have been claimed to induce HC after KTx, the persistence of posttransplant hyperparathyroidism (PT-HPT) of moderate-severe degree is universally considered the first causal factor. Though not proven, there are experimental and clinical suggestions that HC can adversely affect either the graft (nephrocalcinosis) and other organs or systems (vascular calcifications, erythrocytosis, pancreatitis, etc.). However, there is no conclusive evidence that correction of serum calcium levels might avoid the occurrence of these claimed clinical effects of HC. The best way to reduce the occurrence of HC after KTx is to treat as best we can the secondary hyperparathyroidism (SHP) during the uraemic stages. The indication to Parathyroidectomy (PTX), either before or after KTx, in order to prevent or to treat, respectively, HC after KTx, is still a matter of debate which has been revived by the availability of the calcimimetic cinacalcet for the treatment of PT-HPT. However, we still need to better clarify many points as regards the potential adverse effects related to either PTX or cinacalcet use in this clinical set, and we are waiting for the results of future randomized controlled trials to achieve some more definite conclusions on this topic.<\/jats:p>","DOI":"10.4061\/2011\/906832","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T17:34:53Z","timestamp":1308764093000},"page":"1-9","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Impact of Hypercalcemia in Kidney Transplant"],"prefix":"10.4061","volume":"2011","author":[{"given":"Piergiorgio","family":"Messa","sequence":"first","affiliation":[{"name":"Nefrologia, Dialisi e Trapianto Renale, Ospedale Maggiore-Policlinico-Mangiagalli-Regina Elena, IRCCS, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Cafforio","sequence":"additional","affiliation":[{"name":"Nefrologia, Dialisi e Trapianto Renale, Ospedale Maggiore-Policlinico-Mangiagalli-Regina Elena, IRCCS, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Nefrologia, Dialisi e Trapianto Renale, Ospedale Maggiore-Policlinico-Mangiagalli-Regina Elena, IRCCS, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000287430.19960.0e"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.1053\/ajkd.2000.9682","volume":"36","year":"2000","journal-title":"American Journal of Kidney Diseases"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/oxfordjournals.ndt.a027843","volume":"13","year":"1998","journal-title":"Nephrology Dialysis Transplantation"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.09.055"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000203187.49890.cc"},{"issue":"8","key":"6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1056\/NEJM197308232890804","volume":"289","year":"1973","journal-title":"New England Journal of Medicine"},{"issue":"205","key":"7","first-page":"67","volume":"52","year":"1983","journal-title":"Quarterly Journal of Medicine"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01475.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00690.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.03.025"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03920808"},{"issue":"11","key":"12","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.2215\/CJN.02460310","volume":"5","year":"2010","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"6","key":"13","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/ki.1994.473","volume":"46","year":"1994","journal-title":"Kidney International"},{"issue":"6","key":"14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/ki.1982.227","volume":"22","year":"1982","journal-title":"Kidney International"},{"issue":"6","key":"15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ki.1991.314","volume":"40","year":"1991","journal-title":"Kidney International"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01950.x"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00365599409180465","volume":"28","year":"1994","journal-title":"Scandinavian Journal of Urology and Nephrology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01753.x"},{"issue":"11","key":"19","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1111\/j.1600-6143.2007.01978.x","volume":"7","year":"2007","journal-title":"American Journal of Transplantation"},{"issue":"2","key":"20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1681\/ASN.V132551","volume":"13","year":"2002","journal-title":"Journal of the American Society of Nephrology"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01903.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03930808"},{"key":"23","first-page":"ii196","volume":"1","year":"2008","journal-title":"NDT Plus"},{"issue":"8","key":"24","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJM199108223250804","volume":"325","year":"1991","journal-title":"New England Journal of Medicine"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00341.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00251.x"},{"issue":"10","key":"27","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1359\/jbmr.2002.17.10.1768","volume":"17","year":"2002","journal-title":"Journal of Bone and Mineral Research"},{"issue":"21","key":"28","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1093\/hmg\/ddq342","volume":"19","year":"2010","journal-title":"Human Molecular Genetics"},{"issue":"5","key":"29","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0002-9343(68)90206-4","volume":"45","year":"1968","journal-title":"The American Journal of Medicine"},{"key":"30","first-page":"1375","volume-title":"Nephrocalcinosis","year":"1998"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020009"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00684.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000116417.03114.87"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00938.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.12.065"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1159\/000217585"},{"issue":"11","key":"37","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/CIRCRESAHA.108.178095","volume":"102","year":"2008","journal-title":"Circulation Research"},{"key":"38","first-page":"7","volume":"59, supplement 8","year":"2008","journal-title":"Journal of Physiology and Pharmacology"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.189779"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1159\/000102978"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1159\/000210082"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(97)00106-8"},{"issue":"10","key":"43","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1681\/ASN.V3101653","volume":"3","year":"1993","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"44","first-page":"1029","volume":"25","year":"1993","journal-title":"Transplantation Proceedings"},{"issue":"2","key":"45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00007890-199507270-00004","volume":"60","year":"1995","journal-title":"Transplantation"},{"issue":"9","key":"46","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1172\/JCI119769","volume":"100","year":"1997","journal-title":"Journal of Clinical Investigation"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00131.x"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.08.041"},{"issue":"12","key":"49","first-page":"1352","volume":"236","year":"1976","journal-title":"Journal of the American Medical Association"},{"issue":"5","key":"50","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0002-9610(87)90260-1","volume":"154","year":"1987","journal-title":"American Journal of Surgery"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh892"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl583"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm044"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00589.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001549"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn654"},{"issue":"12","key":"57","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.2215\/CJN.02110310","volume":"5","year":"2010","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl560"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000232452.80018.ad"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00500705"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm270"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.041"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000253429.33198.2f"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817c13e1"},{"issue":"7","key":"65","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/TP.0b013e318186b7fb","volume":"86","year":"2008","journal-title":"Transplantation"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm632"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.055"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1159\/000304180"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2010.01.001"},{"issue":"3","key":"70","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1530\/EJE-10-0915","volume":"164","year":"2011","journal-title":"European Journal of Endocrinology"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-10-36"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.549"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh924"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh925"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm632"},{"issue":"4","key":"76","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF00314953","volume":"41","year":"1991","journal-title":"European Journal of Clinical Pharmacology"}],"container-title":["International Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2011\/906832.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2011\/906832.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2011\/906832.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T04:52:58Z","timestamp":1637902378000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijn\/2011\/906832\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":76,"alternative-id":["906832","906832"],"URL":"https:\/\/doi.org\/10.4061\/2011\/906832","relation":{},"ISSN":["2090-214X","2090-2158"],"issn-type":[{"value":"2090-214X","type":"print"},{"value":"2090-2158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}