{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:42:30Z","timestamp":1793900550767,"version":"4.8.0"},"reference-count":212,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Research Council of the K.U.Leuven","award":["STRT1\/10\/044"],"award-info":[{"award-number":["STRT1\/10\/044"]}]},{"name":"Research Council of the K.U.Leuven","award":["G073109N"],"award-info":[{"award-number":["G073109N"]}]},{"name":"Research Council of the K.U.Leuven","award":["G.0604.07"],"award-info":[{"award-number":["G.0604.07"]}]},{"name":"Research Council of the K.U.Leuven","award":["G072409N"],"award-info":[{"award-number":["G072409N"]}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["STRT1\/10\/044"],"award-info":[{"award-number":["STRT1\/10\/044"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G073109N"],"award-info":[{"award-number":["G073109N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G.0604.07"],"award-info":[{"award-number":["G.0604.07"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G072409N"],"award-info":[{"award-number":["G072409N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["STRT1\/10\/044"],"award-info":[{"award-number":["STRT1\/10\/044"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G073109N"],"award-info":[{"award-number":["G073109N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G.0604.07"],"award-info":[{"award-number":["G.0604.07"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G072409N"],"award-info":[{"award-number":["G072409N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["STRT1\/10\/044"],"award-info":[{"award-number":["STRT1\/10\/044"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G073109N"],"award-info":[{"award-number":["G073109N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G.0604.07"],"award-info":[{"award-number":["G.0604.07"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G072409N"],"award-info":[{"award-number":["G072409N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Aging Research"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>The tight interplay between endoplasmic-reticulum-(ER-) and mitochondria-mediated Ca<jats:sup>2+<\/jats:sup>signaling is a key determinant of cellular health and cellular fate through the control of apoptosis and autophagy. Proteins that prevent or promote apoptosis and autophagy can affect intracellular Ca<jats:sup>2+<\/jats:sup>dynamics and homeostasis through binding and modulation of the intracellular Ca<jats:sup>2+<\/jats:sup>-release and Ca<jats:sup>2+<\/jats:sup>-uptake mechanisms. During aging, oxidative stress becomes an additional factor that affects ER and mitochondrial function and thus their role in Ca<jats:sup>2+<\/jats:sup>signaling. Importantly, mitochondrial dysfunction and sustained mitochondrial damage are likely to underlie part of the aging process. In this paper, we will discuss the different mechanisms that control intracellular Ca<jats:sup>2+<\/jats:sup>signaling with respect to apoptosis and autophagy and review how these processes are affected during aging through accumulation of reactive oxygen species.<\/jats:p>","DOI":"10.4061\/2011\/920178","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T18:47:01Z","timestamp":1299610021000},"page":"1-20","source":"Crossref","is-referenced-by-count":107,"title":["IP<sub>3<\/sub>Receptors, Mitochondria, and Ca<sup>2+<\/sup>Signaling: Implications for Aging"],"prefix":"10.4061","volume":"2011","author":[{"given":"Jean-Paul","family":"Decuypere","sequence":"first","affiliation":[{"name":"Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O\/N-1, Herestraat 49, Bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Monaco","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O\/N-1, Herestraat 49, Bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Missiaen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O\/N-1, Herestraat 49, Bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humbert","family":"De Smedt","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O\/N-1, Herestraat 49, Bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B.","family":"Parys","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O\/N-1, Herestraat 49, Bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Bultynck","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O\/N-1, Herestraat 49, Bus 802, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","volume":"1","year":"2000","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1391"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01588-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2006"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1152\/physrev.1996.76.4.1027","volume":"76","year":"1996","journal-title":"Physiological Reviews"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.09.002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2009.05.002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.02.001"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2174\/156652408783769571"},{"issue":"10","key":"10","volume":"2","year":"2010","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"5134","key":"11","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1126\/science.8235595","volume":"262","year":"1993","journal-title":"Science"},{"issue":"2","key":"12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/physrev.1990.70.2.391","volume":"70","year":"1990","journal-title":"Physiological Reviews"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.03.024"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.12.002"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2010.03.002"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.01.007"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-7793.1999.001aa.x","volume":"516","year":"1999","journal-title":"Journal of Physiology"},{"issue":"1","key":"18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1469-7793.2000.00057.x","volume":"529","year":"2000","journal-title":"Journal of Physiology"},{"issue":"215","key":"19","first-page":"re1","volume":"2004","year":"2004","journal-title":"Science's STKE"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03486"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1054\/ceca.1999.0090"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2005.06.030"},{"issue":"5","key":"23","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/emboj\/18.5.1303","volume":"18","year":"1999","journal-title":"The EMBO Journal"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.95.6.1103"},{"issue":"5004","key":"25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1126\/science.2017683","volume":"252","year":"1991","journal-title":"Science"},{"issue":"6329","key":"26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/351751a0","volume":"351","year":"1991","journal-title":"Nature"},{"issue":"26","key":"27","doi-asserted-by":"crossref","first-page":"18776","DOI":"10.1016\/S0021-9258(19)37028-0","volume":"267","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.071403.161303"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.12.003"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.04.005"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.03.015"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506623200"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19980615)52:6<672::AID-JNR6>3.0.CO;2-5"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biolcel.2003.11.004"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00354"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00482"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3580147"},{"issue":"4","key":"38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.200205091","volume":"159","year":"2002","journal-title":"Journal of Cell Biology"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2308"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2952"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400780"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(02)01370-6"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.01.010"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1038\/nature02246"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.835389"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101486200"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1556"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1038\/nature09358"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906484106"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.007"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0723-y"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.02.022"},{"issue":"44","key":"53","doi-asserted-by":"crossref","first-page":"27494","DOI":"10.1016\/S0021-9258(18)47012-3","volume":"269","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(2002)007<0309:AHFCMM>2.0.CO;2"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.10.020"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200608073"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CR0050032"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.07.001"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.036"},{"issue":"3","key":"60","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-3565(24)39299-7","volume":"293","year":"2000","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.021413698"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1038\/nature07534"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.157644"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.01.025"},{"issue":"9","key":"65","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1016\/S0021-9258(18)53280-4","volume":"268","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6569"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0719-7"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.308"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.021507.105852"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408352102"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1302"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702489104"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.096040"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200309146"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907555106"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.06.014"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711324105"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509262200"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1126\/science.1189157"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.11.013"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199405"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/S0143416002001872"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.04.023"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2006"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.22.6349"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.010"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.007"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.02.021"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.10.015"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2245"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2239"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.33"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.12.013"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.12.009"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8383-9"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.01.015"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504035"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.79"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402099"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.114207"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.34"},{"issue":"35","key":"102","doi-asserted-by":"crossref","first-page":"26107","DOI":"10.1016\/S0021-9258(19)74287-2","volume":"268","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05849.x"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.09.003"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1395.001"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1038\/35041709"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.05.004"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081447"},{"issue":"2","key":"109","first-page":"S58","volume":"17","year":"2003","journal-title":"Alzheimer Disease and Associated Disorders"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1297.074"},{"key":"111","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1749-6632.2001.tb05658.x","volume":"928","year":"2001","journal-title":"Annals of the New York Academy of Sciences"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1323.029"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2009.11.002"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.01.001"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02276.x"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.025353"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.08.035"},{"key":"118","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-1-4020-6191-2_11","volume":"45","year":"2007","journal-title":"Sub-Cellular Biochemistry"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.06.005"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.01.001"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30447"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.03.005"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20135"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.015"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000818"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3421"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.4161\/chan.4.1.11537"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211012"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.07.010"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2009.03.001"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.02.006"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200105057"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.12.045"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-007-9414-9"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00324-4"},{"key":"136","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1749-6632.1994.tb44423.x","volume":"747","year":"1994","journal-title":"Annals of the New York Academy of Sciences"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1054\/ceca.1999.0048"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01843-5"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01148.2003"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(96)00269-0"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00127-X"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90883-M"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1256-07.2007"},{"issue":"1","key":"144","first-page":"21","volume":"2","year":"2007","journal-title":"Calcium Binding Proteins"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1042\/BC20070086"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403872200"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040072"},{"issue":"4","key":"148","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1474-9726.2010.00575.x","volume":"9","year":"2010","journal-title":"Aging cell"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12619"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.09.008"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.19.2570"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.1038\/35065638"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1038\/nature02789"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2006.00235.x"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2007.0576"},{"key":"156","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.008"},{"key":"157","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133500"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073651"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00527-X"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094637"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00126-6"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1038\/nature03354"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099196"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040076"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.1126\/science.1118357"},{"key":"167","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.03.018"},{"key":"168","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051351"},{"key":"169","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2009.04.010"},{"key":"170","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082889"},{"key":"171","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031314"},{"key":"172","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1482"},{"key":"173","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.13.1539"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712145105"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.1.10817"},{"issue":"3","key":"177","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4161\/cc.7.3.5360","volume":"7","year":"2008","journal-title":"Cell Cycle"},{"key":"178","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(96)10033-5"},{"key":"179","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135380"},{"key":"180","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138825"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401844200"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.011"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408918200"},{"issue":"13","key":"184","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.4161\/cc.6.13.4457","volume":"6","year":"2007","journal-title":"Cell Cycle"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.12.6746"},{"issue":"12","key":"186","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1096\/fj.01-0206fje","volume":"15","year":"2001","journal-title":"The FASEB Journal"},{"key":"187","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2006.08.002"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087782"},{"key":"189","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2009.03.007"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.03.004"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.11.002"},{"key":"192","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1975"},{"key":"193","doi-asserted-by":"publisher","DOI":"10.1038\/nature08221"},{"key":"194","doi-asserted-by":"publisher","DOI":"10.1038\/nature04724"},{"issue":"4","key":"195","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4161\/auto.2974","volume":"2","year":"2006","journal-title":"Autophagy"},{"key":"196","doi-asserted-by":"publisher","DOI":"10.1038\/nature04723"},{"key":"197","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406960200"},{"key":"198","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605940200"},{"key":"199","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802403200"},{"key":"200","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E09-03-0225"},{"key":"201","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.06.013"},{"key":"202","doi-asserted-by":"publisher","DOI":"10.1038\/nature07006"},{"key":"203","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708818104"},{"key":"204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807735105"},{"key":"205","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200809125"},{"key":"206","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-009-9255-1"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.8.10050"},{"key":"208","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808515200"},{"key":"209","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.7.13286"},{"key":"210","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2012"},{"key":"211","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000298"},{"key":"212","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.256"},{"key":"213","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.7.12113"}],"container-title":["Journal of Aging Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jar\/2011\/920178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jar\/2011\/920178.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jar\/2011\/920178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T21:35:45Z","timestamp":1741037745000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jar\/2011\/920178\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":212,"alternative-id":["920178","920178"],"URL":"https:\/\/doi.org\/10.4061\/2011\/920178","relation":{},"ISSN":["2090-2212"],"issn-type":[{"value":"2090-2212","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}