{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T21:09:29Z","timestamp":1721596169898},"reference-count":42,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Both results of the odor identification and cardiac<jats:sup>123<\/jats:sup>I-metaiodobenzylguanidine accumulation have been investigated for their potential to enhance the detection of pathogenesis resembling that of Lewy body-related<jats:italic>\u03b1<\/jats:italic>-synucleinopathies in patients clinically diagnosed as having idiopathic REM sleep behavior disorder.<jats:italic>Methods<\/jats:italic>. We performed both the Odor Stick Identification Test for Japanese and<jats:sup>123<\/jats:sup>I-metaiodobenzylguanidine scintigraphy in 30 patients with idiopathic REM sleep behavior disorder, 38 patients with Parkinson's disease, and 20 control subjects.<jats:italic>Results<\/jats:italic>. In idiopathic REM sleep behavior disorder, reduced odor identification score and an early or delayed heart to mediastinum ratio on<jats:sup>123<\/jats:sup>I-metaiodobenzylguanidine were almost as severe as in Parkinson's disease patients. Delayed cardiac<jats:sup>123<\/jats:sup>I-metaiodobenzylguanidine uptake was even more severe in the idiopathic REM sleep behavior disorder group than in the Parkinson's disease group.<jats:italic>Conclusions<\/jats:italic>. Reduced cardiac<jats:sup>123<\/jats:sup>I-metaiodobenzylguanidine uptake, which is independent of parkinsonism, may be more closely associated with idiopathic REM sleep behavior disorder than olfactory impairment.<\/jats:p>","DOI":"10.4061\/2011\/941268","type":"journal-article","created":{"date-parts":[[2011,4,17]],"date-time":"2011-04-17T13:33:22Z","timestamp":1303047202000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Idiopathic REM Sleep Behavior Disorder: Implications for the Pathogenesis of Lewy Body Diseases"],"prefix":"10.1155","volume":"2011","author":[{"given":"Tomoyuki","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Neurology, Center of Sleep Medicine, School of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of 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