{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:36:33Z","timestamp":1762673793671,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Alzheimer's Disease"],"published-print":{"date-parts":[[2010]]},"abstract":"We studied the diagnostic value of CSF A\u03b2<\/mml:mi><\/mml:math>42\/tau versus low A\u03b2<\/mml:mi><\/mml:math>1\u201342% and high A\u03b2<\/mml:mi><\/mml:math>1\u201340<\/mml:mn>ox<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:math>% levels for differential diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), respectively. CSF of 45 patients with AD, 15 with DLB, 21 with Parkinson's disease dementia (PDD), and 40 nondemented disease controls (NDC) was analyzed by A\u03b2<\/mml:mi><\/mml:math>-SDS-PAGE\/immunoblot and ELISAs (A\u03b2<\/mml:mi><\/mml:math>42 and tau). A\u03b2<\/mml:mi><\/mml:math>42\/tau lacked specificity in discriminating AD from DLB and PDD. Best discriminating biomarkers were A\u03b2<\/mml:mi><\/mml:math>1\u201342% and A\u03b2<\/mml:mi><\/mml:math>1\u201340<\/mml:mn>ox<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:math>% for AD and DLB, respectively. AD and DLB could be differentiated by both A\u03b2<\/mml:mi><\/mml:math>1\u201342% and A\u03b2<\/mml:mi><\/mml:math>1\u201340<\/mml:mn>ox<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:math>% with an accuracy of 80% at minimum. Thus, we consider A\u03b2<\/mml:mi><\/mml:math>1\u201342% and A\u03b2<\/mml:mi><\/mml:math>1\u201340<\/mml:mn>ox<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:math>% to be useful biomarkers for AD and DLB, respectively. We propose further studies on the integration of A\u03b2<\/mml:mi><\/mml:math>1\u201342% and A\u03b2<\/mml:mi><\/mml:math>1\u201340<\/mml:mn>ox<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:math>% into conventional assay formats. Moreover, future studies should investigate the combination of A\u03b2<\/mml:mi><\/mml:math>1\u201340<\/mml:mn>ox<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:math>% and CSF alpha-synuclein for the diagnosis of DLB.<\/jats:p>","DOI":"10.4061\/2010\/761571","type":"journal-article","created":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T11:45:03Z","timestamp":1282650303000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Combined Analysis of CSF Tau, A\u03b2<\/mml:mi><\/mml:math>42, A\u03b2<\/mml:mi><\/mml:math>1\u201342% and A\u03b2<\/mml:mi><\/mml:math>1\u201340<\/mml:mtext>ox<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:math>% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia"],"prefix":"10.1155","volume":"2010","author":[{"given":"Mirko","family":"Bibl","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, Henricistrasse 92, 45136 Essen, Germany"}]},{"given":"Hermann","family":"Esselmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, 45147 Essen, Germany"}]},{"given":"Piotr","family":"Lewczuk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany"}]},{"given":"Claudia","family":"Trenkwalder","sequence":"additional","affiliation":[{"name":"Paracelsus-Elena Klinik, University of Goettingen, 34128 Kassel, Germany"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Institute for Neurology, University of Ulm, 89075 Ulm, Germany"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, 45147 Essen, Germany"}]},{"given":"Brit","family":"Mollenhauer","sequence":"additional","affiliation":[{"name":"Paracelsus-Elena Klinik, University of Goettingen, 34128 Kassel, Germany"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2007.06.012"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001967"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl063"},{"key":"5","first-page":"1448","volume":"313","year":"1996","journal-title":"British Medical Journal"},{"issue":"7","key":"6","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","year":"1984","journal-title":"Neurology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"issue":"6","key":"8","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","volume":"51","year":"1988","journal-title":"Journal of Neurology Neurosurgery and Psychiatry"},{"issue":"8","key":"9","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1212\/WNL.52.8.1555","volume":"52","year":"1999","journal-title":"Neurology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00818.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305992"},{"issue":"1","key":"12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","volume":"3","year":"1950","journal-title":"Cancer"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.1.2.213"},{"issue":"9","key":"14","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1212\/WNL.54.9.1875","volume":"54","year":"2000","journal-title":"Neurology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.9.1218"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1159\/000083178"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-006-0537-z"},{"issue":"9109","key":"18","first-page":"1105","volume":"351","year":"1998","journal-title":"The Lancet"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1159\/000094871"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01697-9"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1159\/000115975"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(98)00022-0"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700703"},{"issue":"3","key":"24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3233\/JAD-2001-3306","volume":"3","year":"2001","journal-title":"Journal of Alzheimer's Disease"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.058776"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04404.x"},{"issue":"5","key":"27","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/brain\/awl063","volume":"129","year":"2006","journal-title":"Brain"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.06.004"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2008.00064.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.5.2.153"}],"container-title":["International Journal of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijad\/2010\/761571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijad\/2010\/761571.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijad\/2010\/761571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T09:03:40Z","timestamp":1497863020000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijad\/2010\/761571\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":30,"alternative-id":["761571","761571"],"URL":"https:\/\/doi.org\/10.4061\/2010\/761571","relation":{},"ISSN":["2090-0252"],"issn-type":[{"type":"electronic","value":"2090-0252"}],"subject":[],"published":{"date-parts":[[2010]]}}}