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This endocrinopathy may result from the development of a benign lesion (adenoma or hyperplasia) or from a carcinoma. Most of the PHPT cases occur sporadically; however, approximately 10% of the patients present a familial form of the disease. The molecular mechanisms underlying the pathogenesis of sporadic PHPT are incompletely understood, even though somatic alterations in<jats:italic>MEN1<\/jats:italic>gene and CCND1 protein overexpression are frequently observed. The<jats:italic>MEN1<\/jats:italic>gene is mutated in about 30% of the parathyroid tumours and the protooncogene<jats:italic>CCND1<\/jats:italic>is implicated in parathyroid neoplasia by rearrangements, leading to an overexpression of CCND1 protein in parathyroid cells. The aim of this work is to briefly update the molecular alterations underlying sporadic primary hyperparathyroidism.<\/jats:p>","DOI":"10.4061\/2011\/275802","type":"journal-article","created":{"date-parts":[[2011,9,8]],"date-time":"2011-09-08T20:36:05Z","timestamp":1315514165000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Molecular Alterations in Sporadic Primary Hyperparathyroidism"],"prefix":"10.1155","volume":"2011","author":[{"given":"Maria In\u00eas","family":"Alvelos","sequence":"first","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal"},{"name":"Faculty of Engineering of the University of Porto (FEUP), 4200-465 Porto, Portugal"}]},{"given":"Maria","family":"Mendes","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal"},{"name":"Abel Salazar Biomedical Sciences 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