{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:54:18Z","timestamp":1740160458882,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"],"award-info":[{"award-number":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"],"award-info":[{"award-number":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"]}]},{"name":"POCI","award":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"],"award-info":[{"award-number":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"]}]},{"name":"CEMUC-R","award":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"],"award-info":[{"award-number":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"]}]},{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"crossref","award":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"],"award-info":[{"award-number":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"crossref"}]},{"name":"International Postdoctoral Research Fellowship Programme (BIDEB)","award":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"],"award-info":[{"award-number":["PTDC\/QUI\/65732\/2006","PTDC\/QUI\/098562\/2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Electrochemistry"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Fludarabine, 9-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>-D-arabinosyl-2-fluoroadenine, the nucleoside analog, represents a highly effective treatment for hairy cell leukemia. The electrochemical behaviour of fludarabine is an irreversible diffusion controlled oxidation mechanism and was investigated at a glassy carbon electrode in different supporting electrolytes using cyclic, differential pulse, and square wave voltammetry. The diffusion coefficient of fludarabine was calculated to be<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:msub><mml:mi>D<\/mml:mi><mml:mrow><mml:mtext>FLU<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>1.71<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>6<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>\u2009cm<jats:sup>2<\/jats:sup>s<jats:sup>-1<\/jats:sup>in pH 7.0 0.1\u2009M phosphate buffer. The oxidation mechanism of fludarabine occurs with the transfer of one proton and one electron and the formation of a hydroxylated species. The interaction of fludarabine with DNA was investigated, by differential pulse voltammetry, in incubated solutions and using dsDNA- and polyhomonucleotides-, poly[G] and poly[A], electrochemical biosensors. The results showed that fludarabine interacts with DNA causing changes in the DNA structure.<\/jats:p>","DOI":"10.4061\/2011\/340239","type":"journal-article","created":{"date-parts":[[2011,4,17]],"date-time":"2011-04-17T10:06:46Z","timestamp":1303034806000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["<i>In Situ<\/i>Evaluation of Fludarabine-DNA Interaction Using a DNA-Electrochemical Biosensor"],"prefix":"10.4061","volume":"2011","author":[{"given":"H.","family":"Eda Satana","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal"},{"name":"Department of Analytical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, 06330 Ankara, Turkey"}]},{"given":"Ana Maria","family":"Oliveira-Brett","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008325110921"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(94)90072-P"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00303-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2003.10.011"},{"issue":"2-3","key":"5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0009-8981(91)90081-M","volume":"200","year":"1991","journal-title":"Clinica Chimica Acta"},{"issue":"10","key":"6","first-page":"733","volume":"51","year":"1996","journal-title":"Pharmazie"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(99)00189-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1302"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2003.10.055"},{"issue":"1-2","key":"10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-0728(96)05030-9","volume":"427","year":"1997","journal-title":"Journal of Electroanalytical Chemistry"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.06.021"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(97)00007-X"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2008.07.032"},{"year":"1993","key":"14"},{"year":"1996","key":"16"},{"year":"1997","key":"17"}],"container-title":["International Journal of Electrochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijelc\/2011\/340239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijelc\/2011\/340239.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijelc\/2011\/340239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T18:48:49Z","timestamp":1497898129000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijelc\/2011\/340239\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":16,"alternative-id":["340239","340239"],"URL":"https:\/\/doi.org\/10.4061\/2011\/340239","relation":{},"ISSN":["2090-3537"],"issn-type":[{"type":"electronic","value":"2090-3537"}],"subject":[],"published":{"date-parts":[[2011]]}}}