{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:24:56Z","timestamp":1761675896675,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"vor","delay-in-days":327,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"European Community","award":["LSHM-CT-2007-037950","LSHB-CT-2006-037953"],"award-info":[{"award-number":["LSHM-CT-2007-037950","LSHB-CT-2006-037953"]}]},{"name":"European Community","award":["LSHM-CT-2007-037950","LSHB-CT-2006-037953"],"award-info":[{"award-number":["LSHM-CT-2007-037950","LSHB-CT-2006-037953"]}]},{"name":"State Government of North Rhine-Westphalia","award":["LSHM-CT-2007-037950","LSHB-CT-2006-037953"],"award-info":[{"award-number":["LSHM-CT-2007-037950","LSHB-CT-2006-037953"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Alzheimer's Disease"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Cerebrospinal fluid (CSF) samples from 33 patients with Alzheimer dementia (AD), 21 patients with mild cognitive impairment who converted to AD during followup (MCI\u2010AD), 25 patients with stable mild cognitive impairment (MCI\u2010stable), and 16 nondemented subjects (ND) were analyzed with a chemiluminescence immunoassay to assess the levels of the mitogen\u2010activated protein kinase ERK1\/2 (extracellular signal\u2010regulated kinase 1\/2). The results were evaluated in relation to total Tau (tTau), phosphorylated Tau (pTau), and beta\u2010amyloid 42 peptide (A<jats:italic>\u03b2<\/jats:italic>42). CSF\u2010ERK1\/2 was significantly increased in the AD group as compared to stable MCI patients and the ND group. Western blot analysis of a pooled cerebrospinal fluid sample revealed that both isoforms, ERK1 and ERK2, and low amounts of doubly phosphorylated ERK2 were detectable. As a predictive diagnostic AD biomarker, CSF\u2010ERK1\/2 was inferior to tTau, pTau, and A<jats:italic>\u03b2<\/jats:italic>42.<\/jats:p>","DOI":"10.4061\/2011\/739847","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T21:02:24Z","timestamp":1322168544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evidence for Elevated Cerebrospinal Fluid ERK1\/2 Levels in Alzheimer Dementia"],"prefix":"10.1155","volume":"2011","author":[{"given":"Philipp","family":"Spitzer","sequence":"first","affiliation":[]},{"given":"Heinke","family":"Schieb","sequence":"additional","affiliation":[]},{"given":"Heike","family":"Kamrowski-Kruck","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[]},{"given":"Davide","family":"Chiasserini","sequence":"additional","affiliation":[]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[]},{"given":"Johannes","family":"Schuchhardt","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[]},{"given":"Hans-Wolfgang","family":"Klafki","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2011,11,24]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM2003ra020003"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102009\u20101177"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700703"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(06)70355\u20106"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20104580(95)00021\u20106"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165\u20100173(00)00019\u20109"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl280"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102009\u20101167"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900016151"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(75)90026\u20106"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.12.1510"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.02.001"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c47cc2"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/548145"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.596"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2009.106"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.09.022"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2009.008232"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102010\u2010100030"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.14843"},{"key":"e_1_2_7_25_2","article-title":"Emerging role for ERK as a key regulator of neuronal apoptosis","volume":"2004","author":"Cheung E. C.","year":"2004","journal-title":"Science\u2032s STKE"},{"key":"e_1_2_7_26_2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.55782\/ane-2000-1357","article-title":"MAPK regulation of gene expression in the central nervous system","volume":"60","author":"Adams J. P.","year":"2000","journal-title":"Acta Neurobiologiae Experimentalis"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959\u20104388(99)00010\u20100"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.2001.00054.x"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000067426"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-02-01285.1995"}],"container-title":["International Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijad\/2011\/739847.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijad\/2011\/739847.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.4061\/2011\/739847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T08:03:40Z","timestamp":1718697820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.4061\/2011\/739847"}},"subtitle":[],"editor":[{"given":"Charlotte","family":"Teunissen","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.4061\/2011\/739847"],"URL":"https:\/\/doi.org\/10.4061\/2011\/739847","archive":["Portico"],"relation":{},"ISSN":["2090-8024","2090-0252"],"issn-type":[{"type":"print","value":"2090-8024"},{"type":"electronic","value":"2090-0252"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2011-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"739847"}}