{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:45:05Z","timestamp":1762375505339,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Aging Research"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To test the relation between white matter lesions (WML) location and physical performance, in aged patients.<jats:italic>Methods<\/jats:italic>. Subjects: 29 patients (17 males), aged &gt;65 (mean age<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>72.6<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>5.2<\/mml:mn><\/mml:mrow><\/mml:math>), with leukoaraiosis. WML was quantified with a visual scale; Apparent Diffusion Coefficient (ADC) was measured bilaterally in frontal periventricular lesioned white matter and frontal and parieto-occipital normal appearing white matter (NAWM). Motor performance was studied using the Short Physical Performance Battery (SPPB), single leg stand time, finger tapping and grooved pegboard tests (GPT).<jats:italic>Results<\/jats:italic>. There were significant correlations between the frontal region visual scale scores and SPPB chair stands (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn>0.379<\/mml:mn><\/mml:mrow><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.039<\/mml:mn><\/mml:mrow><\/mml:math>) and Grooved Pegboard (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.393<\/mml:mn><\/mml:mrow><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.032<\/mml:mn><\/mml:mrow><\/mml:math>); frontal NAWM ADC values and SPPB standing balance (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn>0.450<\/mml:mn><\/mml:mrow><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.014<\/mml:mn><\/mml:mrow><\/mml:math>) and SPPB 4 meter walk (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>-<\/mml:mo><mml:mn>0.379<\/mml:mn><\/mml:mrow><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.043<\/mml:mn><\/mml:mrow><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. Frontal WML are negatively related to motor performance in patients with leukoaraiosis. DWI results suggest that this may be true even for NAWM.<\/jats:p>","DOI":"10.4061\/2011\/950341","type":"journal-article","created":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T17:32:11Z","timestamp":1305480731000},"page":"1-6","source":"Crossref","is-referenced-by-count":15,"title":["Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis"],"prefix":"10.4061","volume":"2011","author":[{"given":"Miguel","family":"Viana-Baptista","sequence":"first","affiliation":[{"name":"Neurology Department, Hospital de Egas Moniz (CHLO), 1349-019 Lisbon, Portugal"},{"name":"CEDOC, Faculty of Medical Sciences, New University of Lisbon, 1169-056 Lisbon, Portugal"}]},{"given":"Paulo","family":"Bugalho","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital de Egas Moniz (CHLO), 1349-019 Lisbon, Portugal"}]},{"given":"Constan\u00e7a","family":"Jord\u00e3o","sequence":"additional","affiliation":[{"name":"Resson\u00e2ncia Magn\u00e9tica de Caselas, 1400-045 Lisbon, Portugal"}]},{"given":"Olga","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Neuropsychology Department, Hospital de Egas Moniz (CHLO), 1349-019 Lisbon, Portugal"}]},{"given":"Jos\u00e9 Ant\u00f3nio","family":"Esperan\u00e7a-Pina","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medical Sciences, New University of Lisbon, 1200-249 Libson, Portugal"}]},{"given":"Jos\u00e9","family":"Ferro","sequence":"additional","affiliation":[{"name":"Neurology Department, Faculty of Medicine, Hospital de Santa Maria, 1649-035 Lisbon, Portugal"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1001\/archneur.1987.00520130013009","volume":"44","year":"1987","journal-title":"Archives of 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