{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:28:06Z","timestamp":1785234486251,"version":"3.55.0"},"reference-count":98,"publisher":"The Korean Society of Applied Pharmacology","issue":"5","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.biomolther.org"],"crossmark-restriction":true},"short-container-title":["Biomol Ther (Seoul)"],"published-print":{"date-parts":[[2025,9,1]]},"DOI":"10.4062\/biomolther.2025.050","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:57:46Z","timestamp":1754528266000},"page":"747-757","update-policy":"https:\/\/doi.org\/10.4062\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chitinase-3-Like Protein 1 as a Therapeutic Target for Inflammatory Diseases"],"prefix":"10.4062","volume":"33","author":[{"given":"Sun Mi","family":"Gu","sequence":"first","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Whata Bio Co. Ltd., Seoul 05836, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Key-Hwan","family":"Lim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Myoung","family":"Jun","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Ryang","family":"Kweon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Tae","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2506","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2013.09.012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1398.034"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00550.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-34"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.44.26252"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.075846"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1133"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711000149"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6087-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1269-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<span><<\/span>1497::AID-ANR25<span>><\/span>3.0.CO;2-#"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.08.025"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19980615)69:4<span><<\/span>414::AID-JCB3<span>><\/span>3.0.CO;2-Q"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18593"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000444855"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5249"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0868"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.01.005"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303137200"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.12.002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74461-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105550"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-02022-w"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.07.032"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1042\/bj2800309"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/ar3734"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4110\/in.2021.21.e22"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25225"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0543-3"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/32.11.949"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)44:4<span><<\/span>826::AID-ANR139<span>><\/span>3.0.CO;2-U"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.7.618"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.7150\/thno.20183"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2004.11.011"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00026.x"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.498"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.4110\/in.2025.25.e5"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26467"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.764985"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1055"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13478"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2843"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3519"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081271"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12752"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.02.007"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13138"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.739"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15824"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0226-4"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.05.014"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5440"},{"key":"ref53","unstructured":"Matsumoto, T. and Tsurumoto, T. (2001) Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters. <i>Clin. Exp. Rheumatol.<\/i> <b>19<\/b>, 655-660."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1002\/art.10816"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2021.107737"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.622360"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-1723-x"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08513-4"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.12.010"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1027"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.2.1096"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.03.016"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0893-7"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0592-3"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4778"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2015.1123"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5746031"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194591"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2022.577977"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2017.10.001"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.08.029"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014181"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050826"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.680043"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00122"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.18.3442"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00118"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1422OC"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.11.5719"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.17980\/2016.1"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq973"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1074"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw937"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.11.6625"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183294"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407704101"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/920459"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0377"},{"key":"ref90","unstructured":"Volck, B., Price, P. A., Johansen, J. S., Sorensen, O., Benfield, T. L., Nielsen, H. J., Calafat, J. and Borregaard, N. (1998) YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils. <i>Proc. Assoc. Am. Physicians<\/i> <b>110<\/b>, 351-360."},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg034"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.12.1326"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.7.544"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1368"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1211790"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0127-7"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00303-7"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.12.016"}],"container-title":["Biomolecules &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2025\/033\/BT033-05-01.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2025\/033\/BT033-05-01.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T04:47:15Z","timestamp":1757566035000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2025.050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":98,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9,1]]}},"alternative-id":["10.4062\/biomolther.2025.050"],"URL":"https:\/\/doi.org\/10.4062\/biomolther.2025.050","relation":{},"ISSN":["1976-9148","2005-4483"],"issn-type":[{"value":"1976-9148","type":"print"},{"value":"2005-4483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]},"assertion":[{"value":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2025.050","URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2025.050","name":"the_journal","label":"Biomolecules & Therapeutics","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2025 The Korean Society of Applied Pharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}