{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:17:21Z","timestamp":1778739441058,"version":"3.51.4"},"reference-count":25,"publisher":"The Korean Society of Applied Pharmacology","issue":"3","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-RS-2025-02304360"],"award-info":[{"award-number":["NRF-RS-2025-02304360"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00239943"],"award-info":[{"award-number":["RS-2023-00239943"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety of Korea","doi-asserted-by":"publisher","award":["23212MFDS218"],"award-info":[{"award-number":["23212MFDS218"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.biomolther.org"],"crossmark-restriction":true},"short-container-title":["Biomol Ther (Seoul)"],"published-print":{"date-parts":[[2026,5,1]]},"DOI":"10.4062\/biomolther.2025.255","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:40:20Z","timestamp":1777538420000},"page":"556-564","update-policy":"https:\/\/doi.org\/10.4062\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in \u03bc-Opioid Receptor-Mediated ERK Activation"],"prefix":"10.4062","volume":"34","author":[{"given":"Lei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dooti","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Paudel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinru","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Gon","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong-Man","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2506","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62552"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/35047086"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5449.2495"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90196-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197734"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1418"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2010.03.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nature14886"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00585"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179644"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2024.216"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nature19112"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2016.193"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.087254"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506576200"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0137-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90120-G"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0773-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-025-02214-z"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2023.205"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.005942"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.005"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.09.030"}],"container-title":["Biomolecules & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-03-556.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-03-556.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:06:29Z","timestamp":1778738789000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2025.255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.4062\/biomolther.2025.255"],"URL":"https:\/\/doi.org\/10.4062\/biomolther.2025.255","relation":{},"ISSN":["1976-9148","2005-4483"],"issn-type":[{"value":"1976-9148","type":"print"},{"value":"2005-4483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"assertion":[{"value":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2025.255","URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2025.255","name":"the_journal","label":"Biomolecules & Therapeutics","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Society of Applied Pharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}