{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:06:20Z","timestamp":1789373180121,"version":"build-2803163510"},"reference-count":36,"publisher":"The Korean Society of Applied Pharmacology","issue":"5","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002460","name":"Chung-Ang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.biomolther.org"],"crossmark-restriction":true},"short-container-title":["Biomol Ther (Seoul)"],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.4062\/biomolther.2026.012","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:31:43Z","timestamp":1788244303000},"page":"1255-1266","update-policy":"https:\/\/doi.org\/10.4062\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polystyrene Nanoplastics Disrupt Immune Cell Development and Suppress T Cell Activation via mTOR and ERK Signaling"],"prefix":"10.4062","volume":"34","author":[{"given":"Kang-Bin","family":"Dan","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Uk","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeyoung","family":"Min","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"corresponding-author","vocabulary":"crossref"}]}],"member":"2506","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref1","unstructured":"Arthur, C., Baker, J. E. and Bamford, H. A. (2009) Proceedings of the International Research Workshop on the Occurrence, Effects, and Fate of Microplastic Marine Debris, September 9-11, 2008. In University of Washington Tacoma, Tacoma, WA, USA."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26175152"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0629-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114520"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114574"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2009-2837"},{"key":"ref7","unstructured":"Flaherty, S. and Reynolds, J. M. (2015) Mouse na\u00efve CD4+ T cell isolation and <i>in vitro<\/i> differentiation into T cell subsets. <i>J. Vis. Exp.<\/i> <b>98<\/b>, e52739."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jimmunol\/189.9.4203"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2000.imr017517.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.05.018"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0465-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2017.1355293"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747372"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104147"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154907"},{"key":"ref16","unstructured":"Kershaw, P. J. and Rochman, C. M. (2015) Sources, Fate and Effects of Microplastics in the Marine Environment: Part 2 of a Global Assessment. <i>Reports and Studies-IMO\/FAO\/Unesco-IOC\/WMO\/IAEA\/UN\/UNEP Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection (GESAMP) <\/i> Eng No. 93."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-16510-3_12"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12228"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2014.01.019"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.059"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.5c00738"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107199"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.125492"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-021-00414-1"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113970"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/molcells.2016.0160"},{"key":"ref28","unstructured":"Plastics Europe (2020) Plastics-the Facts 2020. An Analysis of European Plastics Production, Demand and Waste Data. Available from: <a href=\"https:\/\/plasticseurope.org\/knowledge-hub\/plastics-the-facts-2020\/\" target=\"_blank\">https:\/\/plasticseurope.org\/knowledge-hub\/plastics-the-facts-2020\/<\/a>."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1080\/10643389.2023.2195798"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2300582121"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6625-7_23"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1021\/jz402234c"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/cells13050454"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131465"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2123795"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37108-5"}],"container-title":["Biomolecules &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1255.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:09:14Z","timestamp":1789369754000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.4062\/biomolther.2026.012"],"URL":"https:\/\/doi.org\/10.4062\/biomolther.2026.012","relation":{},"ISSN":["1976-9148","2005-4483"],"issn-type":[{"value":"1976-9148","type":"print"},{"value":"2005-4483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.012","URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.012","name":"the_journal","label":"Biomolecules & Therapeutics","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2026-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Society of Applied Pharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}