{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:07:14Z","timestamp":1789373234473,"version":"build-2803163510"},"reference-count":30,"publisher":"The Korean Society of Applied Pharmacology","issue":"5","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00343772"],"award-info":[{"award-number":["RS-2024-00343772"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2024-00343772"],"award-info":[{"award-number":["RS-2024-00343772"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.biomolther.org"],"crossmark-restriction":true},"short-container-title":["Biomol Ther (Seoul)"],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.4062\/biomolther.2026.015","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:31:43Z","timestamp":1788244303000},"page":"1192-1206","update-policy":"https:\/\/doi.org\/10.4062\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emodin Induces AIF-Associated Apoptosis and Suppresses Wnt\/\u03b2-Catenin Signaling in Colorectal Cancer Stem-Like Cells"],"prefix":"10.4062","volume":"34","author":[{"given":"Mahdieh","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Department of Life Science and Biomedical Engineering, Graduate School, Sun Moon University, Asan 31460, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Lae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biomedical Engineering, Graduate School, Sun Moon University, Asan 31460, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biomedical Engineering, Graduate School, Sun Moon University, Asan 31460, Republic of Korea"},{"name":"Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Republic of Korea"},{"name":"Genome-Based BioIT Convergence Institute, Sun Moon University, Asan 31460, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"corresponding-author","vocabulary":"crossref"}]}],"member":"2506","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-023-10158-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4409"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2022.26.5.367"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207517"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703478104"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1034"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4591"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13155"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2025.044"},{"key":"ref11","unstructured":"Ma, Q., Ding, Y., Wu, Z. and Li, Y. (2018) Antitumor effects of emodin in CACO-2 human colon carcinoma cells are mediated via apoptosis, cell cycle arrest and downregulation of PI3K\/AKT signalling pathway. <i>J. BUON<\/i> <b>23<\/b>, 587-591."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/396076"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238367"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02272-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5416923"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.08.028"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09684-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2022.20"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.112854"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3445"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/17135"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2952"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2048"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.37349\/etat.2025.1002295"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439675"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.11.012"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.304"}],"container-title":["Biomolecules &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1192.pdf","content-type":"unspecified","content-version":"tdm","intended-application":"text-mining"},{"URL":"https:\/\/pdf.medrang.co.kr\/BT2\/2026\/034\/BT034-05-1192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:09:37Z","timestamp":1789369777000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.4062\/biomolther.2026.015"],"URL":"https:\/\/doi.org\/10.4062\/biomolther.2026.015","relation":{},"ISSN":["1976-9148","2005-4483"],"issn-type":[{"value":"1976-9148","type":"print"},{"value":"2005-4483","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.015","URL":"http:\/\/www.biomolther.org\/journal\/view.html?doi=10.4062\/biomolther.2026.015","name":"the_journal","label":"Biomolecules & Therapeutics","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Online First","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":4,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2026 The Korean Society of Applied Pharmacology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}